Digitoxin in serum
Last reviewed: 23.04.2024
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The concentration of digitoxin in serum when applied to therapeutic doses is 14-26 ng / ml. Toxic concentration is more than 35 ng / ml.
The half-life of digitoxin in adults is 5-7 days.
Digitoxin is a cardiac glycoside, which differs from digoxin by the duration of action, which is associated with better solubility in lipids. Digitoxin is almost completely absorbed in the digestive tract. In the blood serum, digitoxin binds to albumin. Its effect on the contractility of the heart muscle is about the same as that of digoxin. The standard effective dose of the drug is approximately 50% toxic. This is a relatively high value, so you should monitor the concentration of the drug in the blood of patients. The rules of blood sampling and symptoms of intoxication are the same as in digoxin.
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