Medical expert of the article
New publications
Coagulopathy
Last reviewed: 19.11.2021
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Coagulopathy includes a symptom complex that develops with functional or morphological changes in the system of regulation of the aggregate state of the blood (the coagulation system is its functional part).
The coagulation system is maintained by a constant balance between thrombogenesis factors and anticoagulants (normocoagulation), which keeps blood fluidity and the ability to perform basic functions. Any imbalance caused by congenital or acquired pathology, hemopoiesis and blood vessels, leads to the development of two pathological processes: hypercoagulation and hypocoagulation. Coagulopathy can be quantitative (deficiency or surplus of some factor of blood coagulation) and qualitative (changes in activity or structure of factors). Coagulopathy can be hereditary or congenital (genetic defects) or acquired (the effect of chemical toxic substances, infections, intoxications, disruption of protein and lipid metabolism, cancer, hemolysis, etc.). But of the acquired disorders the most frequent are thrombocytopenia associated with impaired bone marrow function (hypoplastic anemia) or with excessive destruction of platelets (Werlhof's disease), thrombocytopathy, severe liver pathology with impaired prothrombin function and hypovitaminosis K (V) -Auren syndrome.
Diagnosis of coagulopathy based on clinical manifestations: for hypocoagulation conditions characterized by increased bleeding, bruising; for hypercoagulable states of thrombus formation and laboratory studies. From instrumental studies, thromboelastography can be used.
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]