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Chondromyxoid fibroma: causes, symptoms, diagnosis, treatment
Last reviewed: 07.07.2025
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Chondromyxoid fibroma (synonym: fibromyxoid chondroma) is a rare benign tumor of the skeleton with a lobular structure consisting of chondroid, myxoid and fibrous structures.
Among bone tumors, it is detected in less than 1% of patients aged 10 to 30 years (more than half of patients). Clinical manifestations are constant pain in the affected segment of the limb. Over time, the intensity of pain increases, lameness and hypotrophy of soft tissues of the limb join in. Often, during palpation, an area of uniform bone thickening corresponding to the affected area is determined. The tumor is most often located in the metadiaphysis of short and long tubular bones. Radiographs and CT reveal a focus of destruction of the cellular-trabecular structure with a fusiform swelling of the affected area of the bone and local destruction of the cortical layer. Scintigraphy shows local hypervascularization of an average of 185%, hyperfixation of the radiopharmaceutical - 475%. Differential diagnostics should be carried out with aneurysmal and solitary bone cysts.
Treatment of chondromyxoid fibroma is surgical - marginal or segmental resection of the affected bone area with plastic surgery of the post-resection defect and, if indicated, bone metal osteosynthesis.
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