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Causes of increased phosphorus in the blood (hyperphosphatemia)
Last reviewed: 06.07.2025
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Hyperphosphatemia (increased phosphorus in the blood) is most often caused by renal failure, but it is also possible with hypoparathyroidism, pseudohypoparathyroidism, rhabdomyolysis, tumor disintegration, metabolic and respiratory acidosis, and after the introduction of excess phosphate. Hyperphosphatemia is observed in acromegaly, hypervitaminosis D, bone diseases (multiple myeloma, fracture healing), diabetes mellitus, Itsenko-Cushing's disease, some cases of Addison's disease, gestosis, and increased muscle work. The period of healing bone fractures is accompanied by hyperphosphatemia, which is considered a favorable sign. Hyperphosphatemia in nephritis and nephrosis 3.2-6.4 mmol/l (10-20 mg%) is one of the unfavorable prognostic signs (the disease is often accompanied by a decrease in the alkaline reserves of the blood).
The clinical manifestations of hyperphosphatemia are due to hypocalcemia and ectopic calcification of soft tissues, including blood vessels, cornea, skin, kidneys, and periarticular tissue. Chronic hyperphosphatemia contributes to the development of renal osteodystrophy.