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The causes of increased phosphorus in the blood (hyperphosphataemia)
Last reviewed: 19.10.2021
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Hyperphosphatemia (increased phosphorus in the blood) is most often due to renal failure, but it is also possible with hypoparathyroidism, pseudohypoparathyroidism, rhabdomyolysis, tumor decay, metabolic and respiratory acidosis, and after the introduction of excess phosphate. Hyperphosphatemia is observed in acromegaly, hypervitaminosis D, bone diseases (multiple myeloma, healing of fractures), diabetes mellitus, Ithenko-Cushing's disease, some cases of addison's disease, with gestosis, increased muscular work. The period of healing of bone fractures is accompanied by hyperphosphatemia, which is considered a favorable sign. Hyperphosphatemia in nephritis and nephrosis 3.2-6.4 mmol / l (10-20 mg%) is one of the unfavorable prognostic signs (the disease is often accompanied by a decrease in alkaline blood reserves).
Clinical manifestations of hyperphosphataemia are caused by hypocalcemia and ectopic calcification of soft tissues, including blood vessels, cornea, skin, kidneys and periarticular tissue. Chronic hyperphosphatemia promotes the development of renal osteodystrophy.