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Rheumatologist, immunologist

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The causes of increase and decrease in phagocytic activity of neutrophils

Alexey Portnov, medical expert
Last reviewed: 19.10.2021

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Diseases and conditions in which the phagocytic activity of neutrophils changes

Increase in the

Antigenic irritation due to bacterial inflammation (prodromal period, period of acute infection) with normal activity of phagocytosis
Leukocytosis
Allergy
Auto-allergic diseases
Enhancement of antibody-dependent cytotoxicity and response to a donor graft

Decrease in the indicator

Chronic inflammatory diseases of bacterial and viral nature
Congenital defects of phagocytic system, Shedyak-Higashi syndrome, Down's syndrome, SLE, collagen diseases, diseases of immune complexes, lack of Ig, complement
Treatment with cytostatics and immunosuppressants
Ionizing radiation
Secondary and primary immunodeficiencies
Neoplasms
Heavy burns, injuries, stress
Intestinal and renal protein loss syndromes
Malnutrition
Insufficiency of phagocytosis
Chronic inflammation