C-reactive protein ultrasensitive in blood

For a long time, it was considered that an increase in the concentration of C-reactive protein above 5 mg/l was clinically significant, with values below this value indicating the absence of a systemic inflammatory response. Later, it was shown that CRP concentration values exceeding 3 mg/l are an unfavorable prognostic sign associated with the risk of vascular complications in apparently healthy people and patients with cardiovascular diseases. In this regard, ultra-sensitive test systems and reagent kits were developed based on the modification of immunoturbidimetric and immunonephelometric methods with immobilization of antibodies on latex particles. These methods have approximately 10 times greater analytical sensitivity compared to traditional ones and allow recording minimal fluctuations in the concentration of C-reactive protein in the blood even within the limits of “traditional” reference values.

The development of ultra-sensitive test systems is associated with the emergence in clinical practice of the term "basal level of CRP" - the concentration of C-reactive protein in the blood serum, stably detected in apparently healthy individuals, as well as in patients in the absence of an acute inflammatory process or outside of an exacerbation of the disease. It is to determine the basic level of C-reactive protein that highly sensitive analysis methods are used. The value of the basic level of C-reactive protein is of great practical importance, since it is directly related to the risk of developing severe cardiovascular diseases and complications - myocardial infarction and stroke. With a concentration of CRP in the blood below 1 mg / l, the risk of developing vascular complications is minimal, 1.1-1.9 mg / l - low, 2.0-2.9 mg / l - moderate, more than 3 mg / l - high. An increase in the concentration of CRP in the blood serum reflects the activity of inflammation, which is associated with the activity of atheromatosis even before the development of myocardial infarction or stroke. In this regard, an increase in the concentration of CRP should be considered as a sign of atherosclerosis. In patients with coronary artery disease, an initially high level of CRP should be considered as a high-risk factor for the development of restenosis during angioplasty and delayed complications after coronary artery bypass grafting.

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