Betadine during pregnancy

Betadine is an antiseptic drug for topical use, which is very popular among doctors as a drug that is not contraindicated during pregnancy, although its appointment should pay attention to important details: the period of pregnancy, the absence of contraindications, allergies to the constituent components of the medication.

The active substance of betadine is called povidone-iodine. It includes iodine and polyvinylpyrrolidone, which inhibits iodine irritability.

[1], [2]

Indications of the betadina in pregnancy

Depending on the diagnosed disease and the methods of its treatment, different forms of release of Betadine are used.

In the form of candles :

• vaginitis with acute or chronic course;
• bacterial vaginosis (gardnerellez);
• candidiasis;
• vaginal infections caused by inadequate antibacterial or steroid therapy;
• prevention and disinfection of female genital organs before gynecological manipulations;
• infectious colpitis;
• thrush.

In the form of ointment:

• skin infections;
• bedsores and trophic ulcers.

In the form of a solution:

• disinfection of hands before surgeon's interventions;
• preparation of the operating field;
• treatment of wounds and burns;
• disinfection of skin areas around drains, catheters, probes;
• treatment of skin before puncture, biopsy, injections;
• disinfection of the birth canal during labor.

[3], [4]

Release form

Betadine is available in three forms: vaginal suppositories, ointment and solution.

The solution is used for optimal prevention of infection on wound surfaces. Also for the treatment of lesions due to burns, in surgical practice for disinfection and treatment of the hands of the surgeon, the operating field.

Vaginal suppositories give a therapeutic effect in gynecological infectious and viral, fungal diseases.

Ointment "Betadin" is effective for infectious, bacterial, fungal infections of the skin, infectious dermatitis, pressure sores, trophic ulcers, burns, abrasions, wounds.

[5], [6]

Pharmacodynamics

Betadine has antiseptic, disinfectant, antiviral, antimycotic and antiprotozoal effects. It is a drug of wide impact.

The microorganisms to which betadine is affected:

• bacteria ( E. Coli, Staphylococcus aureus, Gardnerella );
• mushrooms Candida;
• the simplest ( Trichomonas );
• viruses.

Its mechanism of action: iodine, released in the mucous membrane, blocks the amino acids that make up the basis of proteins and enzymes of the pathogenic microorganism. This contributes to the death or lulling of cellular structures.

[7], [8]

Pharmacokinetics

Betadine begins to act 15-20 seconds after it has been applied to the mucous membrane or skin surface. The total death of pathogenic microorganisms occurs 1 minute after the drug has come into contact with the affected tissues.

If betadine is taken for an extended period, absorption of iodine is observed, which leads to an increase in iodine in the blood plasma. Normalization of the level of iodine is observed 8-15 days after the end of the drug because iodine has a large molecular weight and as a result, its absorption and excretory excretory system deceleration.

After vaginal administration of betadine, the half-life of the betadine takes two days.

[9], [10], [11], [12], [13]

Dosing and administration

The ointment is applied topically to the skin surface. Before the betadine comes into contact with the injured mucous membrane, it must be cleaned and dried dry. Ointment is applied a thin layer, after which it is recommended to apply a sterile bandage. Wounds with the infectious infection are treated with betadine twice a day for two weeks.

The solution can be applied externally in diluted and undiluted form. Betadine is recommended for warming up to body temperature. Do not dilute the product in hot water. In undiluted form, betadine is used in the disinfection of skin before medical manipulation. For the hygienic cleaning of the hands take 3 ml of the drug 2 times. During the disinfection of the hands before surgery: 5 ml of betadine 2 times. The solution is applied 2-3 times for 24 hours. When treating wound surfaces and burns, prescribe betadine, diluted with saline solution or Ringer's solution.

Suppositories must be removed from the blister and moistened with warm water. Suppositories need to be introduced to a greater depth in the vagina, preferably before bedtime. They can also be used during menstruation. During the use of vaginal suppositories, it is recommended to use daytime pads. The drug is applied once a day with acute vaginitis throughout the week, with subacute and chronic - two weeks. The standard treatment cycle is 14 days, it can be increased on the recommendation of the attending physician.

[18]

Use of the betadina in pregnancy during pregnancy

Most doctors do not recommend using betadine during pregnancy, because they fear that iodine, which is part of the drug, can affect the normal functioning of the thyroid gland of the future baby. Other doctors in their practice use betadine, appointing it to pregnant women. However, this is done with extreme caution and under the supervision of a doctor.

During the period of gestation, the woman's immunity decreases and any microorganism that could not cause an inflammatory reaction before the pregnancy due to optimal immune protection can lead to inflammation of the genitals, for example, to vaginosis, vaginitis, candidiasis (thrush). Overcooling, exacerbation of chronic diseases, uncomfortable underwear, improper compliance with personal hygiene rules - all these are risk factors for the development of the disease during pregnancy.

Depending on the period of pregnancy, the risk of undesirable effects of the drug on the development of the fetus varies. The first trimester includes the period of laying down and differentiating the organs and systems of the child. This is the initial stage of the formation of a new organism. Since the thyroid gland is still absent at this time, the use of betadine is for the most part safe.

In the second trimester of pregnancy, the period of the laying of organs and systems comes to an end, their full formation takes place, including the thyroid gland. Therefore, starting from the fourth month, doctors are trying not to introduce betadine into the list of prescriptions for pregnant women.

In the third trimester of pregnancy, the use of betadine is also not recommended. However, each individual case must be considered. If the risk of negative consequences of the disease in a woman exceeds the risk of betadine exposure to the fetus, the drug may be prescribed, but with great care. It is necessary to conduct control studies of the development of the thyroid gland in a child: its size and functioning.

A month before the birth of the child, his thyroid gland begins to produce thyroid hormones, and the placenta becomes a barrier to the intake of these hormones of the mother's body to the fetus.

The drug betadine is effective in the form of suppositories with urogenital infections of pregnant women, which can be dangerous for the development of the fetus. He can be prescribed to treat thrush in the future mother.

If a pregnant woman gets angina, flu, pharyngitis, laryngitis, a  solution of betadine can help in the fight against inflammation. It contains glycerol, which softens the effect of iodine on the mucous membranes. Betadine in this form of release can be used, including for disinfection of the birth canal during childbirth.

The standard scheme of treatment with betadine during pregnancy: the use of suppositories 2 times a day for a week, or one vaginal candle per day for 14 days. But do not forget that the doctor does all the appointments and he chooses the period of application.

Some women may be frightened of vaginal discharge when taking suppositories "Betidin" in the period of bearing a child. One of the reasons for this phenomenon is that the suppository inside melts and its residues can go outside.

Contraindications

The drug is not prescribed if the patient has an individual sensitivity to iodine or other constituents of the drug, herpetiform dermatitis of Dühring, impaired functional kidney function, renal, cardiac and hepatic insufficiency.

In pathological conditions of the thyroid gland such as: hyperthyroidism, goiter, adenoma..

Betadine in suppositories is not attributed simultaneously with other antiseptics and disinfectants.

[14], [15], [16]

Side effects of the betadina in pregnancy

Local side effects of betadine include local fever, itching and redness, swelling of the skin, the emergence of contact dermatitis. These symptoms disappear when the drug is withdrawn.

If betadine is used for a long time, generalized side effects may occur that require urgent elimination because of complex complications:

• an allergic reaction in the form of anaphylactic shock;
• impaired kidney function and development of renal failure;
• metabolic acidosis;
• hyperthyroidism due to an overabundance of exogenous iodine intake into the body;
• violation of blood supply;
• lowering of blood pressure.

[17]

Overdose

Overdose with betadine leads to the development of anuria, heart failure, swelling of the larynx, pulmonary edema, metabolic disorders.

In this case, in order to save the patient's life, it is necessary to introduce food rich in starch content. Gastric lavage with a solution of sodium thiosulfate 5% The initial task of the person providing first aid.

[19], [20], [21], [22]

Interactions with other drugs

Betadine is not recommended to appoint simultaneously with drugs containing hydrogen peroxide, silver, toluidine, since the active substances of these drugs lead to a decrease in the effectiveness of betadine.

The drug is not used with preparations containing mercury, as this will result in the formation of an alkaline iodide of mercury.

Betadine is incompatible with the salts of alkaloids, tannic and salicylic acids, silver, bismuth salts.

[23],

Storage conditions

Optimal storage temperature: 5 - 15 C. The place of saving should be protected from direct sunlight and moisture. Betadine should be stored in a place inaccessible to children.

[24], [25], [26], [27]

Shelf life

Shelf life: 36 months. At the end of this period, the medicine is not to be used.

[28], [29]

Analogues

Analogues betadina is a drug, among the components of which there is a similar active substance - povidone-iodine. It:

• Yodoxide;
• Iodosept;
• Iodovidone;
• Aquazan;
• Betadine.

[30], [31], [32], [33], [34]

Pimafucin or betadin?

Pimafucin is used to treat diseases caused by fungi, for example, thrush. This disease is often manifested in pregnant women. The drug has no effect on the fetal organism, therefore it is actively used during gestation. This is due to its mechanism of action: the active substance natamycin is not absorbed from the digestive tract and does not enter the bloodstream, that is, it can not penetrate the baby's body. Natamycin combines sterols of membranes, breaks their structure and functions, as a result of which pathogenic microorganisms perish. The main contraindication to its use is individual intolerance.

Betadine can affect not only mycosis diseases, but also bacterial, viral, and infectious diseases. That is, it has an effect on a greater number of microorganisms, hence, helps in the fight against a large number of diseases. However, due to the fact that the composition of this drug includes iodine, it can harm the fetus.

Each of the drugs is used in individual cases.