Fluuomycin during pregnancy

Antiseptic antifungal agent for local therapy of urogenital infections Fluomizine during pregnancy is allowed, but only as directed by the doctor, since there is no clinically valid data regarding the safety of its use during the first two trimesters of pregnancy.

[1], [2], [3], [4]

Indications of the fluomizine during pregnancy

It is possible to apply Fluomizine during pregnancy in the 3rd trimester - with the aim of prenatal sanation of the cervical canal and vagina if there are infections in them after the 34th week.

Fluomizin in the planning of pregnancy is prescribed for the treatment of bacterial vaginitis (colpitis), vulvovaginitis, vaginal candidiasis (thrush), trichomoniasis and gardnerelleza.

[5],

Release form

Fluuomisin is available in the form of vaginal tablets.

Pharmacodynamics

Fluymisin's local therapeutic effect - bacteriostatic and antifungal - is provided by the included dequalinium chloride, which is a cationic ammonium salt (an ammonia derivative) with antiseptic and surface-active properties; on АТХ has the code R02AA02 and refers to preparations for the treatment of throat diseases.

Dequalinium chloride is active against many strains of streptococcus (including group B), Staphylococcus aureus, Escherichia, entero-and fusobacteria, Gardnerella, Trichomonas, Candida fungus.

When the substance is exposed to bacteria and fungi, the impermeability of the membranes of their cells is broken, and then the cells themselves are destroyed.

[6], [7], [8], [9]

Pharmacokinetics

Manufacturer Fluomizin asserts that with topical application there is a slight systemic absorption of the drug penetrating the blood through the cervico-vaginal mucous epithelium. However, studies have shown the presence of traces of the active substance in the liver, kidneys and lungs.

Biotransformation of dequalinium chloride, which enters the bloodstream, occurs in the liver; Inactive metabolites are excreted through the intestine.

[10], [11], [12]

Dosing and administration

Fluomizin is intended for intravaginal use: one tablet (at night). The standard duration of treatment is six days.

[15], [16], [17]

Contraindications

Fluomizin is contraindicated in the case of erosion of the cervix and in case of violation of the integrity of the mucous vagina, as well as to girls before defloration.

It is undesirable to use Fluuomycin during pregnancy in 1 and 2 trimester trimester.

[13]

Side effects of the fluomizine during pregnancy

Among the side effects of this drug are: hyperemia of the mucosa; the occurrence of itching and burning in the vagina; mucous or spotting after fluomizine during pregnancy; rashes on the skin.

With increased sensitivity to the substances of the drug, hyperthermia is possible.

[14]

Overdose

Information about an overdose of fluomizine is absent.

[18], [19], [20]

Interactions with other drugs

Fluomizin is incompatible with any means for washing the body.

Storage conditions

Fluomizine tablets should be stored at room temperature.

[21], [22]

Shelf life

The shelf life of the drug is indicated on the package.

[23]