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Rinofluimucil during pregnancy

, medical expert
Last reviewed: 25.02.2021
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Medicines during pregnancy - even for the treatment of a cold - should be prescribed by the attending physician, and, as formulated in the instructions, assess the ratio of the expected benefits for the pregnant woman and the possible risk for the unborn child.

In some versions of the instructions, it is noted that Rinofluimucil during pregnancy is prescribed according to this principle.

Can Rinofluimucil be dripped during pregnancy? It will not work to drip, since this product is available in the form of a spray. But the main thing is that the instructions of the manufacturer of this drug (the Italian company Zambon) indicate that it is not recommended to use it during pregnancy, either in the early or late stages.

Indications Rinofluimucil during pregnancy

Rinofluimucil is intended for the treatment of rhinitis (nasopharyngitis) and inflammation of the paranasal sinuses (sinusitis, sinusitis) of an acute, subacute and chronic nature with the formation of a viscous nasal secretion - serous-purulent, as well as vasomotor rhinitis with obstructed nasal breathing. [1]

Pharmacodynamics

The pharmacological action of the drug is provided by its components: the sympathomimetic tuaminoheptane sulfate (2-aminoheptane)  [2]and the mucolytic acetylcysteine, a derivative of the aliphatic sulfur-containing amino acid cysteine.

Acetylcysteine dilutes bronchial and nasal mucus by depolymerizing proteoglycan and glycosaminoglycan molecules, breaking covalent bonds in their anionic sulfate amino groups.

Tuaminoheptane acts as a topical decongestant - narrowing the vessels of the nasal mucosa and relieving its swelling.

Pharmacokinetics

When applied topically (intranasally), the bioavailability of acetylcysteine does not exceed 3%. It is noted that the Rinofluimucil spray does not enter the bloodstream, therefore it does not act systemically.

Contraindications

Rinofluimucil is contraindicated in hyperthyroidism, severe arterial hypertension, angle-closure glaucoma, pheochromocytoma. It is not prescribed for children under 12 years of age and patients who have undergone surgery on the pituitary gland and dura mater of the brain.

Side effects Rinofluimucil during pregnancy

The drug can cause side effects in the form of an allergic reaction (urticaria, swelling of the face, difficulty breathing); nausea and vomiting; dryness of the mucous membranes of the mouth and nasopharynx; increased heart rate and blood pressure; violations of urination; tremors and nervous excitement.

Like all intranasal anticongestants, Rinofluimucil is capable of causing tachyphylaxis and dependence.

Dosing and administration

The agent is injected into the nasal cavity using a nebulizer with a dispenser (one press on the valve of which corresponds to one dose).

Adults are recommended to inject two doses to each nasal passage (no more than four times a day); children 12-16 years old - one at a time.

The maximum permissible duration of use is five days.

Overdose

An overdose of Rinofluimucil leads to an increase in such side effects as high blood pressure, tachycardia, tremor, agitation; and symptomatic treatment is applied to eliminate them.

Interactions with other drugs

Among the drug interactions of Rinofluimucil, its incompatibility with drugs to lower blood pressure (beta-blockers) is noted; cardiotonic agents of the group of cardiac glycosides; with tricyclic antidepressants and psychotropic drugs of the group of monoamine oxidase inhibitors (MAO); dopaminergic drugs for the treatment of Parkinson's disease.

Storage conditions

The drug should be stored at normal room temperature.

 

Shelf life

Rinofluimucil is valid for 30 months (unopened); opened bottle - three weeks.

Analogs

Analogs of this drug should thin the thick nasal secretion and ensure normal breathing through the nose; these include Nazol and Nazalong sprays, Pinosol drops, Aqua Maris spray. Read more -  How to treat a runny nose during pregnancy?

Reviews

Acetylcysteine is a substance that has not been tested to be safe for pregnant women. In the instructions of Rinofluimucil, there is no information that tuaminoheptane sulfate was previously used as a stimulant, since it releases the neurotransmitter norepinephrine and inhibits its reuptake. In 2011, the World Anti-Doping Agency (WADA) included this substance on the list of prohibited substances.

Reviews of obstetricians-gynecologists regarding the use of this drug during pregnancy concern cases of increased uterine tone in pregnant women who are not safe to use Rinofluimucil in the first trimester of pregnancy.

In addition, foreign studies have shown that norepinephrine reuptake inhibitors taken in the 3rd trimester of pregnancy increase the risk of postpartum hemorrhage. Therefore, Rinofluimucil in the 3rd trimester of pregnancy is also not worth using - even in the most extreme cases.

The authors of Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment note that sympathomimetics  [3]taken at the end of pregnancy can reduce the contractility of the uterine muscles, that is, lead to a weakening of labor, and can cause tachycardia in the fetus. [4]

 

Attention!

To simplify the perception of information, this instruction for use of the drug "Rinofluimucil during pregnancy" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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