Rennie in Pregnancy

Rennie in pregnancy is a remedy that is widely used to treat heartburn, which worries women in late pregnancy. The safety of this agent for the fetus is widely discussed, but it is also important that its effectiveness is high. Therefore, before using the drug to treat heartburn, you need to know some of the pharmacological features to decide exactly whether it can be taken and under what conditions.

Basic principles of Rennie's use during pregnancy

Is it possible to drink Rennie and is this drug harmful during pregnancy? This question is asked by many women who use this drug, but since it has its own characteristics of pharmacological action, it is necessary to take into account the different options and individual characteristics of women.

Pregnancy is the period when another woman's life develops in the female body and at this time one should take a very careful attitude to the nutrition and reception of any pharmacological preparations. The process of organogenesis begins in the first trimester, and then the growth and differentiation of tissues continues, which also requires increased attention to taking any medications.

Fetus is an agent alien to the body of a woman, in fact 50% of the information it contains from the pope. The immune system of a woman perceives it as an antibody to some extent, therefore, until the formation of its placenta with an individual barrier and blood flow, a state of relative immunosuppression develops. Such a state of a pregnant woman helps to change all the reactions of the female body, which before could be normal. That is, pharmacological transformation reactions of drugs also occur in a different way, which in this way can significantly affect the child. This especially applies to the first trimester of pregnancy, when there is still no placenta, as an individual protective mechanism. With this, and related features of the application of Rennie at different times of pregnancy.

Rennie during pregnancy in the early stages of taking is not recommended, as any other medication, because the instruction says that there are no contraindications to the prescription, but it must be used with caution and in the exact dosage.

Rennie during pregnancy in later terms can be used without fear, which often happens, because it is in the third trimester of pregnancy that there are changes in the normal functioning of the gastrointestinal tract in the form of heartburn. This is due to the fact that the digestive system during the gestation of a child due to the influence of hormones - prostaglandins - varies in such a way that hypotension of the gastrointestinal tract occurs. In this case, the lower esophageal sphincter can not normally contract and there is an atony or involuntary relaxation, which contributes to the reflux of the acid content of the stomach. The intensification of reflux precisely in the late stages of pregnancy also occurs because of the enlarged uterus, which presses on the stomach and intestines. This is accompanied by complaints of heartburn and nausea, vomiting. This symptom worries a woman for a very long time, which makes it necessary to look for methods of solving the problem - alternative drugs or medications. Rennie is one of the drugs that can be used in this case.

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Pharmacodynamic features of the preparation

The form of the drug is chewing tablets with different pleasant fruit tastes, which further inclines to the choice of this drug, although this is a subjective characteristic.

The mechanism of action of the drug is its protective effect on the stomach and its antacid properties. The drug contains in its composition active substances in the form of calcium carbonate and magnesium carbonate, due to which the effect of the drug is expressed.

The active components of the drug after they are in the stomach, promote the connection with the hydrochloric acid radicals and, as a result, it is neutralized with the formation of calcium and magnesium salts. So, the neutralizing ability of the drug is revealed. An additional Rennie effect is protective. It is explained by the stimulation of the synthesis of bicarbonates in the stomach cavity under the influence of magnesium, which helps protect the mucosa from aggression factors. The calcium of the drug has the ability to be absorbed into the circulatory system by 10%, and magnesium by 20%, which must be taken into account when possible concomitant conditions and drug overdose. The effect of the drug is rapid, it comes in 5-10 minutes after the application of the drug.

Indications for use Rennie - is a disease of the intestines and stomach, which are accompanied by increased basal secretion of hydrochloric acid. Rennie is also recommended in the complex therapy of duodenal ulcers and stomach ulcers, as well as as a preventive treatment of this pathology. Other indications for use are acute gastroduodenitis, heartburn, Zolinger-Alison syndrome, diet disorders, which are accompanied by increased unpleasant sensations in the stomach.

Pharmacokinetic features of the drug

As a result of taking the drug inside, calcium and magnesium salts are formed, which are partially absorbed into the blood, and partially in a complex of insoluble compounds are excreted with feces. The part that sucked into the blood is excreted through the kidneys. The increase in the amount of the drug in the blood is possible with violations of their excretion. There is no direct teratogenic effect of Rennie, it is able to penetrate the fetoplacental barrier only in the smallest concentrations in the form of composite calcium and magnesium, which explains its minimal threat to the fetus.

Methods of application and symptoms of an overdose

Overdose of the drug can be observed with concomitant diseases of the kidneys, which will be manifested by a violation of the stool by the type of diarrhea, and with a chronic overdose, there are symptoms of elevated calcium levels in the blood.

The method of application of the drug - it must be chewed until complete dissolution. Dosage - one tablet, then two hours later you can take more if the symptoms have not passed. The maximum number of tablets that can be taken during pregnancy should not exceed 16.

The interaction of Rennie with other drugs is that it reduces the absorption of other medications, so the gap between the use of another drug and Rennie should be at least two hours.

The storage conditions of Rennie are as follows: shelf life is five years. Store at a relative temperature below 25 degrees, avoiding direct action of high and low temperatures, and also to exclude high humidity. Keep away from children.

Rennie in pregnancy can be successfully used as a symptomatic treatment for heartburn, which often worries pregnant women in late pregnancy. It must be taken into account that the dosage of the drug should not be exceeded, since side effects are possible. Given the low absorption of the drug in the blood, it can be taken during pregnancy without harm to the fetus.

Contraindications to admission and its side effects

Rennie in pregnancy can not be used in case of acute disorders or serious pathologies on the part of the liver and kidneys, as well as in the presence of allergic reactions in the anamnesis or in case of allergies to additional composite components of the drug. With caution, it is necessary to prescribe the drug with an elevated level of calcium in the blood, because there may be an overdose, as well as with an increased level of magnesium.

Side effects of Rennie during pregnancy in case of its use in the first trimester are possible violations of differentiation of the fetal tissues and violation of the placentation, which is not proved by clinical trials, there is only a theoretical concept. Also, allergic reactions may occur during the administration of the drug and changes in the nature of the stool in the form of diarrhea, changes in color or constipation. Possible side effects with concomitant disorders of kidney function in the form of hypermagnesemia and hyperkalemia. Often, one of the side effects in the form of the development of the "rebound" syndrome - with the symptoms of heartburn disappear only for a while, and after stopping the drug the symptoms become even worse. It is also possible to have an adverse event in the form of an increase in the blood sugar level with concomitant diabetes, since the preparation contains a significant amount of sucrose.

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