Meti Prep for Pregnancy

Some pregnant women sometimes for some reason violate the hormonal background, which leads to the predominance of male hormones over female hormones. This can lead to serious problems, including miscarriages. That is why many doctors recommend using Metizred during pregnancy. Its active ingredient is methylprednisolone.

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Indications for Metipred use in pregnancy

As a rule, during pregnancy, this drug is prescribed if there is a threat of loss of the fetus. This is especially important when the patient already had miscarriages earlier. Among other things, "Metipred" not only helps to suppress male hormones in the body of a pregnant woman, but also to increase the production of female hormones. It eliminates the main signs of allergy, removes puffiness and inflammation.

Form of issue

This drug is released in two basic forms: in the form of tablets (with a different dosage of methylprednisolone: 4 mg and 16 mg), as well as lyophilizate to create a solution (a powder that dissolves for injection). In all forms of release, the main active ingredient is methylprednisolone, although this solution in the form of sodium succinate is used.

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Pharmacodynamics

Has anti-allergic, anti-inflammatory immunosuppressive effect. When methylprednisolone enters the body, it begins to interact with cytoplasmic receptors and form a complex that induces protein production.

Among other things, the main active ingredient of Metipred helps to reduce the amount of such substance as serum globulin, promotes the synthesis of albumins in hepatocytes, and enhances the synthesis of fatty acids. It promotes the redistribution of fat, causes hyperglycemia.

Anti-inflammatory effect of the drug is to reduce the permeability of capillaries, stabilize the cell membranes and organelles. Cell membranes become less susceptible to damage of various kinds.

Since this agent is immunosuppressive, it inhibits the proliferation of lymphocytes and inhibits the release of cytokines.

Pharmacokinetics

After the product enters the body, it begins to absorb fairly quickly, with about 70% of methylprednisolone being discharged. First of all, the substance is metabolized in the liver. When using powder to create a special injection solution is absorbed very quickly and completely. At the same time, its bioavailability is 89%.

When using the injection solution, the maximum concentration of the substance occurs after 1.5 hours. The dose of the drug does not matter, it almost always binds to proteins in the plasma by 62%.

The drug is excreted by the kidneys. One day after receiving Metipred 85% of the drug can be found in the urine.

Dosing and Administration

Dosage of this drug should be a specialist. It is used "Metipred" during pregnancy only under the professional supervision of a professional. Typically, the average dose is as follows: half a tablet a day (if a woman is just planning to become pregnant). When the pregnancy has already come, the doctor must individually adjust the method of application. Many women take the drug before delivery.

Remember that you can not stop taking Metipred on your own, as this can lead to a miscarriage.

Early pregnancy in pregnancy

If this remedy is prescribed in the early stages, it strengthens the immunity of the expectant mother, reduces the amount of the male hormone and reduces the possibility of developing a miscarriage. But notice, if you have already started taking this drug, then you need to do this until the end of pregnancy. Only in very rare cases the doctor cancels the use of Metipred.

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The cancellation of Metipred during pregnancy

The abolition of the drug during pregnancy is gradual. The course can not be interrupted too abruptly, as this can lead to unpleasant and rather serious side effects. The most famous among them are: severe pain in the muscles, fever, lack of adrenal work (early stage).

Metipred when planning pregnancy

Recently, many women face the problem of conception. At similar complaints it is necessary to pass or take place inspection at the endocrinologist. After putting all the tests, the specialist will be able to see which hormone drug is needed in this or that case. Especially popular is Metipred.

For women who plan to become pregnant, this drug is prescribed:

1. If the female body is dominated by the male hormone testosterone. This is one of the most important reasons for Metipred's reception.
2. If there is a threat of miscarriage during pregnancy or they have already happened in the past. Especially often this remedy is prescribed to improve the hormonal background immediately after an arbitrary abortion.
3. With myoma of the uterus, the drug helps to accelerate conception.

When planning a pregnancy, many women decide not to take "Metipred" after the doctor's recommendation. This is fraught with the development of secondary infertility. Also prednisolone (the main active substance of the drug) differs anti-edematous and anti-inflammatory effect, which is very important if you plan to become pregnant.

Side effects of Metipred during pregnancy

"Metipred" is a serious hormonal drug that leads to the appearance of serious diseases, especially if the dosage is prescribed incorrectly. The most common side effects of Metipred are:

1. Endocrine obesity and a person in the form of the moon (the so-called Itenko-Cushing syndrome).
2. Oppression of the adrenal glands.
3. Development of diabetes mellitus.
4. Frequent manifestations of nausea, which is accompanied by vomiting.
5. Development of gastric ulcer.
6. Bleeding in the digestive tract.
7. Thrombosis.
8. Arrhythmia.
9. Headache.
10. Depression and hallucinations.

Contraindications for use

The only contraindication to the use of the drug is the intolerance of its components. But "Metipred" should be used with extreme caution:

• With various diseases of the digestive tract (for example, ulcer, gastritis, esophagitis, divertulitis).
• Patients who are ill with parasitic, fungal and infectious diseases (herpes, measles, mycosis, chicken pox, amebiasis, latent tuberculosis).
• Before and after the administration of some vaccines.
• In diseases of the heart and blood vessels (myocardial infarction, arterial hypertension).
• Patients with endocrine diseases (thyrotoxicosis, obesity, hypothyroidism).
• With systemic osteoporosis.

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Overdose

Overdose of the drug during pregnancy leads to increased serious side effects. To improve the condition is usually only enough to reduce the dosage for a while.

Interactions with other drugs

If "Metipred" is simultaneously assigned with:

1. Phenobarbital, Phenytoin, Ephedrine, Rifampicin may reduce the amount in the body of methylprednisolone.
2. Amphotericin B and diuretics often causes an increase in the excretion of potassium from the body, which increases the risk of heart and vascular disease.
3. Drugs based on sodium causes an increase in blood pressure and the appearance of edema.
4. Anticoagulants (indirect) can lead to an increase or decrease in the effect of these drugs.
5. Thrombolytics leads to bleeding in the gastrointestinal tract.
6. Paracetamol can cause increased hepatotoxicity.
7. Vitamin D worsens the absorption of calcium.
8. Androgens and steroid anabolic drugs leads to hirsutism, acne and edema.
9. Immunosuppressants increase the risk of developing lymphoma and various infections.
10. Antacids reduces the absorption of methylprednisolone.

Storage conditions and shelf life

"Metipred" in tablet form should be stored in a place inaccessible to children. The air temperature can not exceed +25 degrees. Powder for solution for injection is stored in an inaccessible place, away from sunlight. The air temperature can not exceed +25 degrees. If the solution has been restored, it should be stored in the refrigerator (temperature not above +8 degrees).

Shelf life of the drug is five years. The reconstituted solution is stored only for a day. Please note that taking Metizred after the expiry date may lead to side effects.