Suppositories with papaverine during pregnancy

All future mothers are convinced that during pregnancy it is better to refrain from taking medications. Many of them are afraid of negative consequences for themselves and for the baby.

Unfortunately, it is not always possible to avoid drug treatment in the long nine months. However, there are many drugs that will only benefit the pregnant woman and will not harm the future baby. In the list of such drugs necessarily there is a place for suppositories with papaverine. During pregnancy, they are often used and give an excellent result.

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Indications for the use of suppositories with papaverine

In the first place, the suppository with papaverine during pregnancy is designed to reduce the tone of the uterus. This complaint is the most common among pregnant women. In addition, the tone is a serious threat to the health and life of the baby.

Spasmolytic properties of the drug also affect the vessels: papaverine gently reduces high blood pressure.

Suppositories perfectly eliminate the pain caused by spasms of the internal organs. Papaverin can help out in many situations, when you need antispasmodics or vasodilators.

"How does papaverine affect a baby's development?" Is the suppository with papaverine harmful during pregnancy? "- doctors who monitor pregnancy often hear such questions in their offices. Future moms can be calm. The influence of papaverine on the health of a child can not be worried. The drug has been taken by more than one generation of pregnant women, and not one million babies have appeared since then. Side effects that affect the baby, for this time have not been identified. It can be safely asserted that the safety of papaverine is checked not only by the necessary clinical trials, but also for years.

The names of suppositories from different manufacturers differ slightly:

• Papaverine;
• Papaverine hydrochloride;
• Suppositories with papaverine hydrochloride.

Pharmacodynamics and pharmacokinetics

The drug is absorbed in the stomach and small intestine. After entering the blood, it binds to plasma proteins. Papaverine accumulates in the body, lingering, mainly, in fatty tissues and in the liver. The kidneys and the liver cleave papaverine almost completely, and the remaining insignificant quantity is naturally deduced in an unchanged form. Papaverine is not addictive.

Papaverin interferes with the action of the phosphodiesterase enzyme. Consequently, the cyclic adenosine monophosphate loses its ability to disintegrate, lingering in the tissues of the smooth muscles, as well as in the striated muscles, preventing them from contracting. Large doses of papaverine may reduce the heart rate.

Method of application of suppositories with papaverine during pregnancy

The manufacturer's instruction indicates that the daily dosage of papaverine is 2-3 candles. They are administered rectally at the same intervals.

First trimester

In the first weeks of pregnancy, when the placental barrier is not yet formed, the list of safe medications is very small. Therefore, as antispasmodics of the suppository with papaverine in the early stages of pregnancy are very much in demand.

At the beginning of pregnancy a woman may suffer from toxicosis, so it is better to refuse tablets to relieve spasms. In addition, the effect of suppositories is much longer: the active substance is absorbed more slowly and the result from the action of papaverine in suppositories can be felt for a whole day.

Until the 16th week, excessive uterine tension is most often caused by a low concentration in the body of the pregnant hormone progesterone. For this reason, the papaverine suppository is combined with hormone therapy.

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Second trimester

At this time, the list of approved medicines is much broader, so drugs of more radical action, for example, ginipral or magnesia, can be used to preserve the health of women and her baby.

Suppositories with papaverine are already used as a remedy for pain sensations or for lowering the pressure to maintain the condition of a pregnant woman until she can consult a doctor.

Third trimester

Suppositories with papaverine in late pregnancy are prescribed if the term of labor has not yet come, and the tension of the uterus is too strong. In the last days before the birth, the suppository will perfectly perform the role of a kind of indicator of "training" fights. If papaverine could remove them, this means that the birth has not yet begun. After the 38th week of pregnancy, the suppository is prescribed to prepare for delivery of the cervix. In addition, they can reduce pain in the first bouts.

In case of an overdose of papaverine, vision may be impaired, lethargy and severe drowsiness may appear. Also this is fraught with too sharp a drop in pressure.

Side effects of papaverine suppositories appear in isolated cases and entirely depend on the individual characteristics of the organism. It can be nausea, drowsiness, excessive sweating, an allergic reaction, problems with the natural emptying of the intestine.

Contraindications to the use of suppositories exist only if the liver is damaged in the work of the pregnant woman, there are problems with the thyroid gland, tachycardia is detected and intraocular pressure is increased.

Papaverine interacts with other drugs, such as barbiturates, some antidepressants. In these cases, the effect of suppositories is enhanced. But future moms have no relation to these subtleties, because drugs with such an effect during pregnancy are not prescribed because of their negative impact on the future child.

Shelf life of suppositories with papaverine is 2 years if the storage conditions are observed at a temperature of no higher than 25 degrees in a darkened place.

The popular idea today is that pregnancy and childbirth is natural for a woman, and any interference in their course can be harmful. However, modern future mothers for many reasons can not always ensure themselves compliance with sleep and rest and avoid daily stress. All this is fraught with certain problems. Suppositories with papaverine during pregnancy are an easy way to solve a significant part of them. Before using suppositories, consult with your doctor.