Vitamins with hyaluronic acid

Vitamins with hyaluronic acid are vitamin-mineral complexes or biologically active additives (BAA). Different manufacturers produce products with different compositions, combining hyaluronic acid with vitamins A, C, E, macroelements and substances of plant origin.

The following names of vitamins with hyaluronic acid are available for sale: biocomplex Vitamins with hyaluronic acid, Doppelherz Beauty Lifting complex with hyaluronic acid (Queisser Pharma, Germany), vitamins with hyaluronic acid Laura (RF), Solgar hyaluronic acid (USA), KWC Hyaluronic Acid (Japan), Premhyal capsules (hyaluronic acid and selenium), etc.

It should be noted that in some pharmacological classifications, preparations containing hyaluronic acid (Acidum hyaluronicum) or, most often, sodium salt of hyaluronic acid - sodium hyaluronate (as well as chondroitin and glucosamine sulfates) are classified as correctors of bone and cartilage tissue metabolism. These preparations can be injected into joints (and this is the only way to use them in the West) or taken orally. But vitamins containing hyaluronic acid are undoubtedly dietary supplements, or, at best, orthomolecular agents.

Indications for the use of vitamins with hyaluronic acid

Hyaluronic acid + vitamin complexes are recommended for use as an auxiliary means for improving metabolism - for age-related skin problems (dryness, loss of turgor, appearance of wrinkles), for inflammatory joint diseases and degeneration of cartilaginous tissue (arthrosis, coxarthrosis, osteochondrosis), for a number of ophthalmological pathologies (dry keratoconjunctivitis, destructive processes in the vitreous body of the eye and damage to the cornea).

They are also proposed to be used for preventive purposes - in surgical treatment of diseases in ophthalmology and after cosmetic plastic surgeries. However, there is no confirmation of the effectiveness of using vitamins with hyaluronic acid, since this requires clinical trials, which are not carried out in the production of dietary supplements.

Contraindications to the use of vitamins with hyaluronic acid include age under 15 years, individual hypersensitivity or intolerance to the substances included in their composition (in particular allergies), increased or decreased levels of platelets in the blood and severe renal dysfunction.

The use of vitamins with hyaluronic acid during pregnancy and lactation is contraindicated.

The main form of release of these vitamin supplements is tablets or capsules.

Pharmacodynamics

Today, there is no requirement for biologically active supplements to explain the specific mechanisms of action of their components on biochemical processes in the body, therefore, in the description of vitamins with hyaluronic acid, most often general information is provided, and occasionally - for each substance included in their composition.

First of all, it is hyaluronic acid itself, which is contained in most cells of the body. But in particularly high concentrations, it performs a vital anatomical function in the structure of the extracellular elastin-collagen matrix of the basal layer of the epidermis, in the composition of connective tissues, synovial fluid of the joint cavity and the vitreous body of the eye. Hyaluronic acid is an acidic glycosaminoglycan (mucopolysaccharide) - a negatively charged heteropolysaccharide, that is, a carbohydrate polymer. Its helical molecule consists of a repeating sequence of two disaccharides (D-glucuronic acid and DN-acetylglucosamine) and has a high molecular weight (in the range from 1 to 1.5 million Da). Due to the presence of hydrophilic carboxyl groups, hyaluronic acid is able to bind water molecules in the collagen matrix in a ratio of 1:1000.

But the statements of some manufacturers that "hyaluronic acid activates fibroblasts and stimulates collagen synthesis" are not explained in any way from the point of view of biochemistry. In addition, not a single manufacturer of vitamin dietary supplements indicates what kind of hyaluronic acid they used: low-molecular animal origin or synthesized sodium hyaluronate, the size of the molecules of which is too large for absorption by endothelial cells of the gastrointestinal tract.

Pharmacokinetics

How the components of dietary supplements are transformed in the body and how they are excreted from it, that is, the pharmacokinetics of vitamins with hyaluronic acid, is not studied: this is also not required in the production of food additives.

It is known that endogenous hyaluronic acid in the body tissues disintegrates in about 72 hours, and in the epidermis - in a day. Therefore, the process of its synthesis is continuous, but with age, unfortunately, it slows down.

What happens to hyaluronic acid taken orally in a tablet or capsule of a dietary supplement is described by manufacturers as follows: “hyaluronic acid contained in the preparation stimulates the synthesis of collagen and elastin.”

However, if hyaluronic acid is a complex carbohydrate, then in the gastrointestinal tract - under the action of enzymes of saliva, gastric juice and intestinal enzymes-glucosidases - it should split into disaccharides, and these will have to turn into monosaccharides and their derivatives. But hyaluronic acid is a heteropolysaccharide and, binding with cell proteins, is part of complex biochemical complexes. Only the enzyme hyaluronidase is capable of splitting endogenous hyaluronic acid into disaccharides (glucuronic acid and acetylglucosamine).

But the salivary enzyme lysozyme can cope with hyaluronic acid included in dietary supplements. But let us repeat once again: manufacturing companies either do not conduct biochemical studies of the metabolism of dietary supplement components or do not advertise their results...

Doppelherz with hyaluronic acid

Doppelherz Beauty Lifting Complex with Hyaluronic Acid or Doppelherz Vitamins with Hyaluronic Acid, according to the manufacturer, contain 100 mg of hyaluronic acid in each capsule. This dietary supplement also contains:

• Biotin or vitamin B7 – 150 mg (triple the daily dose); its deficiency causes various skin problems, as well as muscle pain and depressive states.
• 6 mg of vitamin B5 (pantothenic acid) covers 120% of the daily human requirement. This vitamin is recommended for progressive alopecia, joint pain and cramps, as well as in cases of deterioration of vision and memory.
• lipophilic antioxidant tocopherol (vitamin E) - 20 mg, which is twice the daily physiological norm of its intake into the body. Vitamin E is able to increase the formation of hemoglobin, collagen and muscle proteins, and also prevents the oxidation of vitamin A and unsaturated fatty acids. Half of the tocopherol taken orally first enters the lymph (absorbed in the stomach), and then into the systemic bloodstream, binding to plasma proteins.
• beta-carotene (an isomer of vitamin A), participates in the synthesis of proteins and acidic mucopolysaccharides.
• Vitamin C is distinguished by its particularly active participation in tissue metabolism and collagen synthesis.

Dietary supplement vitamins Doppelherz with hyaluronic acid also contains trace elements: zinc (for better restoration of tissue cells) and selenium, which has antioxidant properties and stimulates metabolism.

Method of administration and dosage: one capsule per day, during meals. Duration of administration is 30 days, repeated use is possible a month after the end of the first course.

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Biocomplex with hyaluronic acid

According to the accompanying instructions, the Vitamins with Hyaluronic Acid biocomplex can help against scars and adhesions after surgeries, and also help restore lost skin tone. And this should be ensured by the glycosaminoglycans containing hyaluronic acid, collagen powder, salmon milk extract, pig placenta powder, vitamin C, elastin peptide (from tuna), sucrose ester and fatty acids included in its composition.

As a commentary, we note that sodium (or calcium) salt of deoxyribonucleic acid obtained from salmon milt "is absorbed by the body and stimulates performance." Collagenol (collagen powder) contains protein, polysaccharides and a premix of vitamins C and E. The lipophilic fraction of pig placenta tissue (very popular in the Far East) is rich in biologically active ingredients, including trace elements and vitamins.

Elastin peptides from tuna bones and skin are made up of alpha-amino acids and are peptide biogenic regulators that are thought to stimulate cellular metabolism. And sucrose fatty acid ester is simply the food gel-like emulsifier E473.

Method of use and dosage of this dietary supplement: 2-3 tablets per day (during meals) for a month.

Solgar Vitamins

Solgar Vitamin Complex with Hyaluronic Acid - Hyaluronic Acid 120 mg (Solgar Vitamin&Herb, USA) - contains hydrolyzed collagen, chondroitin sulfate and vitamin C and is recommended as an adjuvant for joint pathologies (pain and stiffness) and age-related dermatological and cosmetic problems.

We have already discussed hyaluronic acid and vitamin C, but here is what you should know about chondroitin. Chondroitin sulfate is part of cartilage and synovial fluid, is directly related to the synthesis of cartilage tissue, tendons and ligaments, and also promotes the formation of collagen and the synthesis of hyaluronic acid. Moreover, chondroitin sulfate can reduce the activity of lysosomal hyaluronidase, an enzyme that breaks down hyaluronic acid.

We recommend that you carefully read the instructions for dietary supplements: they should only use chondroitin sulfate with a low molecular weight (from salmon cartilage), so that when taken orally it can be absorbed in the gastrointestinal tract and then “integrated” into the affected tissues of human cartilage.

Solgar vitamins with hyaluronic acid are taken during meals - one tablet per day.

Vitamins Laura

Anti-aging vitamins with hyaluronic acid Laura contain (in addition to hyaluronic acid), vitamins (C and E), as well as an alkaloid of the perennial herbaceous vine dioscorea (yam) - diascorine.

This plant alkaloid promotes activation of endogenous synthesis of the steroid hormone dehydroepiandrosterone (DHEA) by the adrenal glands. In turn, DHEA stimulates the production of androgens, estrogens and at least a dozen other important hormones, including the polypeptide growth hormone somatotropin (STH). Somatotropin increases the synthesis of muscle, bone and connective tissue proteins, as well as collagen and chondroitin.

Since the level of DHEA after 30-35 years begins to gradually decrease, then stimulation of its production (and simultaneously the synthesis of somatropin in the pituitary gland) has a positive effect on the condition of the skin. But it should be borne in mind that excess STH can lead to the development of diabetes mellitus and functional disorders of the thyroid gland (hypothyroidism).

It is recommended to take this dietary supplement for a month - one tablet per day (with meals).

Reviews of vitamins with hyaluronic acid

Mostly, reviews of vitamins with hyaluronic acid are negative, although there are also positive comments based on personal experience of their use. Of course, we should not forget that there are no drugs that help absolutely everyone without exception. And this applies primarily to dietary supplements.

It is also important to remember that hyaluronic acid is a major component of healthy skin, with about half of the body's hyaluronic acid found in the dermal matrix. In a study conducted at Otsuma Women's University in Japan, 96 women aged 22 to 65 took vitamins with hyaluronic acid from a Japanese company - three capsules a day for a month and a half. At the end of the study, 80 women reported that their skin had become more hydrated and smooth, and even that acne scars had diminished.