In the instruction indications for the use of caffeine in diet pills are absent: this purine methylxanthine alkaloid belongs to the group of psychostimulating substances affecting the central nervous system.
The caffeine names used are: 1,3,7-trimethyl-xanthine (chemical); caffeine-benzoate sodium or caffeine sodium benozoate (pharmaceutical); alternative - methylteobromine, theine, guaranine.
Indications of caffeine in diet pills
Indications caffeine-sodium benzoate encompass a spectrum of diseases of the central nervous and cardiovascular systems with spasms, reduction of vascular tone and blood pressure, as well as narcolepsy and asthenic states of fatigue, sleepiness and general loss of strength.
Additionally, caffeine-sodium benzoate (caffeine tablets) have become used to reduce body mass, since its mechanism of action extends not only to certain functions of the autonomic nervous system, but also on the metabolic processes by which - via neurotransmitters (transmit pulses Chemicals) - controls the brain.
Form release caffeine-benzoate sodium tablets, powder, solution for injection (10 and 20%) in ampoules.
Pharmacodynamics: How Caffeine Helps Burn Fat
The mechanism of action, that is, the pharmacodynamics of sodium caffeine-benzoate, is based on several biochemical processes. First, caffeine depresses the effector cell enzyme phosphodiesterase, which regulates the transfer of intracellular signals, and this is reflected in an increase in the concentration of the cAMP-cyclic adenosine monophosphate generating hormone. As a result, cAMP increases the activity of fat cell enzymes (adipocytes) that break down triglycerides, and thus the intensity of lipolysis in cells of visceral adipose tissue increases.
An important role is played by the similarity of the chemical structure of caffeine (the methylated purine base of xanthine) to the molecular structure of the adenosine produced by the body, a purine neurotransmitter that inhibits brain excitation. Molecules of caffeine can bind to adenosine receptors in brain cells and do not allow them to activate, that is, they act as a competitive antagonist. But for the fat burning process, the key is that this antagonism promotes the release and activation of catecholamine neurotransmitters, including adrenaline.
Adrenaline acts on membrane adrenoreceptors of adipose tissue cells and also stimulates enzymes involved in the cleavage of triglycerides.
In addition, the effect of caffeine in diet pills is associated with its diuretic effect, which arises from the inhibition of water reabsorption in the renal tubules. However, an increase in the volume of urine is observed only with a dose of caffeine of more than 300 mg.
Caffeine, like most psychostimulants, suppresses appetite, that is, delays the signal of hunger, but the mechanism of this effect is not yet known.
Caffeine-sodium benzoate is well absorbed in the digestive tract (within 30-45 minutes), enters the systemic circulation (the connection with serum proteins does not exceed 15%) and is distributed in tissues and interstitial fluids; penetrates through the BBB.
More than 90% of caffeine is metabolized by the enzymatic system of the liver by demethylation and oxidation to active and inactive metabolites. Among the primary active dimethylxanthines, paraxanthin plays a special role in the activation of lipolysis, and the content of glycerol and free fatty acids increases in blood plasma.
The drug is not cumulated. The half-life of the biotransformation products of sodium caffeine-benzoate averages 4.5-6 hours; excretion - through the kidneys (with urine) and through the intestines (with feces).
Use of caffeine in diet pills during pregnancy
Caffeine penetrates the placenta and enters the breast milk; for this reason, its use during pregnancy and during lactation is contraindicated.
Sodium caffeine-benzoate is contraindicated if there is a history of hypersensitivity to caffeine, hyperexcitability of the central nervous system, epilepsy, cardiovascular pathologies of an organic nature, myocardial infarction, tachycardia, arterial hypertension, chronic insomnia, glaucoma. The drug is not used in the elderly and children under 12 years of age.
Side effects of caffeine in diet pills
The main side effects of caffeine tablets are expressed in the form of nervousness, tremor, headache, sleep disorders, cardiac arrhythmias, increased blood pressure, nausea, pain in the epigastric region. Allergic reaction with urticaria and pruritus.
A significant increase in urine output may lead to dehydration. Also, long-term use of caffeine sodium benzoate there is a risk of dependence - caffeinism. And the sudden discontinuance of possible hypersomnia and depressive distance.
Dosing and administration
Caffeine in diet pills is taken orally, but there are different approaches to its dosage.
According to one recommendation, it is necessary to take 100 mg for every 30 kg of body weight, and only before physical training (for 40-45 minutes); others argue that the optimal dose is 10-20 mg per kilogram of body weight.
Some sources indicate the maximum single dose of caffeine in tablets - 400 mg, and daily - 1 g.
Specialists of the American Medical Association consider a moderate dose of caffeine 200-300 mg per day. Half of this amount is recommended to take a quarter of an hour before breakfast (thereby reducing the appetite for at least half a day), the second reception - 15-20 minutes before lunch (but no later than 16 hours).
Excess dosage of sodium caffeine-benzoate leads to pain in the stomach, nausea, vomiting, nervous overexcitation, increased heart rate, heat, tremor and convulsions.
In case of overdosage, it is necessary to wash the stomach, take activated charcoal: with convulsions, intravenous injections of anticonvulsants, in particular, benzodiazepines, are made.
Interactions with other drugs
Caffeine-sodium benzoate enhances the action of analgesics (not opioid), antipyretic agents, alpha and beta-adrenomimetics, thyreotropic drugs.
Caffeine reduces the effect of tranquilizers, opioid analgesics, soothing and hypnotic drugs.
Enhance the effects of caffeine for hormonal contraception; antibiotics slow down the elimination of caffeine and increase its concentration in the blood plasma.
The use of caffeine concurrent with cardiac glycosides increases not only their therapeutic effect, but also side effects.
Caffeine is absolutely incompatible with the drugs that depress the central nervous system, in particular, drugs for general anesthesia.
Caffeine-sodium benzoate should be stored at room temperature, in a place inaccessible to children.
Shelf-life of the drug is 4 years.
Real testimonials lost weight and the results are not published in the available sources, obviously due to the fact that caffeine-sodium benzoate is not advertised by pharmaceutical companies that produce it.
A few reviews of doctors reduced to the fact that caffeine may slightly reduce body weight or prevent its increase, but "no convincing evidence that the use of caffeine leads to a significant or permanent weight loss, no."
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To simplify the perception of information, this instruction for use of the drug "Caffeine in tablets - for weight loss" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.
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