Drugs used to regulate delivery

This hub on medications for the regulation childbirth covers stages and timelines, preparation checklists, typical examinations, and safety warning signs.

Anticholinergics and antispasmodics: central and peripheral action

Excitation of muscarinic cholinergic receptors of the myometrium causes increased hydrolysis of phosphoinositides, activation of phospholipase A2, activation of protein kinase C, and contraction.

Dopaminergic drugs: place in therapy

Levodopa. Dihydroxyphenylalanine (DOPA) is a biogenic substance formed in the body from tyrosine and is a precursor to dopamine, which in turn is converted to norepinephrine and then to adrenaline.

Beta-blockers during labor: when they are prescribed and the risks

Anaprilin (propranolol, obzidan, inderal). Anaprilin is a specific beta-blocker. The drug is well absorbed from the gastrointestinal tract, making it suitable for oral administration. The optimal dose (blood concentration of Anaprilin after oral administration) is determined within 45 to 120 minutes.

Antiadrenergic drugs: use during labor

Clonidine (gemiton, catapresan, clonidine) has a pronounced hypotensive effect. Clonidine is used in therapeutic practice to treat hypertension. It has been shown that late toxicosis in pregnancy increases blood catecholamine levels, and clonidine administration leads to hypotensive, sedative, and mild diuretic effects.

N-anticholinergics: what are they and why are they prescribed?

Gangleron. This medication has ganglionic blocking, central anticholinergic, antispasmodic, and anesthetic effects. Gangleron is a stable substance that slowly hydrolyzes in the body. It dilates blood vessels, causing a hypotensive effect.

When is the antispasmodic analgesic baralgin used?

Theoretically, any substance that, in a proportionate dose, reduces acetylcholine-induced smooth muscle spasm can be used as an antispasmodic. In practice, however, not all anticholinergic substances are used as antispasmodics.

Analgesics: pain relief in obstetrics

Promedol (trimeperidine hydrochloride). Promedol is a synthetic morphine substitute with a pronounced analgesic effect. Promedol-induced reduction in pain sensitivity develops within 10-15 minutes of subcutaneous administration.

Muscle relaxants: central and peripheral action

In recent years, centrally acting muscle relaxants have become widely used in clinical practice. Unlike peripherally acting muscle relaxants, they do not inhibit spontaneous breathing and do not have adverse effects on the cardiovascular system or other vital organs and systems.

Tranquilizers during labor: indications and safety

Minor tranquilizers include trioxazine, nozepam, phenazepam, sibazon (seduxen, diaerepam), and others. Trioxazine has a moderate tranquilizing effect, combined with activation and some mood elevation without drowsiness or intellectual retardation. It does not have a muscle relaxant effect.

Prostaglandins: use in labor induction

Since 1970, natural prostaglandins have been used as therapeutic agents in obstetrics and gynecology for cervical ripening and early termination of pregnancy, for the purpose of labor induction and stimulation.

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