Spazmoanalgetik perfection

The composition contains three active ingredients: analgesic, spasmolytic and parasympathomimetic. As is known, the pathological processes occurring in the human body are often accompanied by spasms of smooth muscles. An important role in this process is played by acetylcholine, especially its excess content. These processes can be controlled with the help of anticholinergics.

Theoretically, any substance that in a proportionate dose weakens the spasm of smooth muscles caused by acetylcholine can be used as an antispasmodic. In practice, far from all anticholinergic substances are used as antispasmodics. The fact is that, in addition to antispasmodic action, anticholinergic substances affect the function of the heart, sweat and salivary glands, etc., which in some cases is undesirable. In addition, some of them, especially M-holinolitiki in relatively small doses cause a disorder of the central nervous system. Spasms of smooth muscles are caused not only by acetylcholine, but also by other spasmogens - histamine, serotonin, barium ions. Thus, the typical antagonist of acetylcholine - atropine nevertheless manifests its spasmogenic activity in different ways. In this regard, we cite the classification of antispasmodics, depending on the location and mechanism of elimination of smooth muscle spasms. All antispasmodics are divided into three main groups:

• neurotropic antispasmodics: alkaloids solanaceae - atropine; semisynthetic gomatropines, atropine derivatives - methyl bromide; synthetic paraspasmolytics - adiphenine hydrochloride;
• musculotrophic antispasmodics: opium alkaloids - papaverine; analgesics - metamizole - sodium; nitrite - pentanolinitris;
• neuromuscularotropic antispasmodics: simple - akamilofenina hydrochloride; combined (spasmoanalgesics) - baralgin.

In particular, baralgin consists of neurotropic, musculotropic and analgesic components. The first component acts like papaverine, and therefore it is ranked among the group of musculotropic antispasmodics with a steady effect. It is absorbed directly by smooth muscle cells, which means that it stops spasms of smooth muscles regardless of the innervation of the organ. In addition to a pronounced myotropic effect, this substance also has some milder neurotropic (parasympatolytic) and antihistamine action. As a result, even this one property can be obtained neuromuscularotropic spasmolytic effect.

The second component is a typical representative of neurotropic antispasmodics, acting like atropine, but without its side effects. The parasympatolytic action of this substance is based on the displacement of acetylcholine, or, more precisely, this substance competes with acetylcholine in the fight for cholinergic receptors and thus blocks the transfer of impulses to the peripheral parasympathetic nervous branching of smooth muscles. This component also acts as a vagotrophic gangliopligic with a blockade of parasympathetic ganglia.

The third constituent element is a strong central analgesic. Relieves pain of the most diverse origin and in spastic conditions contributes to an increase in the effect produced by the spasmolytic components of the baralgina. Due to its own miotropic action, this substance is a synergist of the first component.

Thus, the advantage of baralgina can be formulated as follows: a carefully selected combination of antispasmodics with neurotropic musculotropic action and a strong central analgesic opens up wide possibilities for the use of the drug in obstetric practice and other branches of clinical medicine. The synergistic effect of individual components can reduce dosage and thereby reduce side effects - atropine and papaverine. The drug is a strong antispasmodic and analgesic without a narcotic effect, the toxicity of the drug is minimized, as the pyrazolone component does not cause adverse reactions. The value of the drug is also that it can be used intravenously, intramuscularly, inside and in candles.

The drug lowers blood pressure (systolic) by 15-17 mm Hg. Art. And diastolic - by 10-12 mm Hg. Art. The heart rate decreases by 10-13 beats / min. The drug does not affect central venous pressure. Baralgin is widely used with a high therapeutic effect for some spastic conditions in surgical and urological practice.

In obstetric practice in recent years, baralgin also has become more widespread.

The main indications for the use of baralgina are the lack of biological readiness for childbirth, premature passage of amniotic fluid, coordinated labor. In the presence of a delayed pregnancy, pelvic presentation of the fetus, as well as preparation for childbirth, the authors recommend using baralgin in the form of tablets or suppositories 3-4 times a day with a duration of treatment from 3 to 10 days. Timely and correct administration of baralgina allows one to achieve a two-fold reduction in the length of labor.

Methods of applying baralgina: intramuscularly or intravenously, 5 ml are injected, repeated administration is recommended after 6-8 hours. With intravenous administration, the effect of baralgina begins immediately, with intramuscular injection, after 20-30 minutes. The daily dose - 20-40 drops 3-4 times a day, or 2-3 candles, or 1-2 tablets 3 times a day.