Fluxostat in Pregnancy

Thrush is a common female disease, provoked by yeast-like fungi. Thrush does not pass independently, it must be treated. In principle, at present, pharmacies offer a lot of effective drugs for this disease, including flucostat. However, is it possible to have flucostat during pregnancy?

After all, in this important period for a woman, the appearance of thrush can represent a real threat to the pregnancy and the health of the baby, and the use of many drugs during pregnancy is prohibited. How to be?

Indications for the use of flucostat in pregnancy

Fluxostat is contraindicated in pregnancy. In rare cases, with the creation of certain conditions, a fungal lesion can cover the entire body. A severe generalized course of candidiasis with damage to external and internal tissues and organs can lead to a fatal outcome in 75% of cases. In this case, the lack of necessary therapy, even an ordinary thrush in the vagina or in the mouth can go into a large-scale chronic fungal infection. Often this contributes to other serious diseases that disrupt immune protection in the body: diabetes, leukemia, HIV infection.

If such a situation is created, that the primary focus is not so much on the actual state of pregnancy and on the preservation of the fetus as on the life of the pregnant woman, then in this case the use of flucostat is allowed.

In all other cases, the use of the drug in pregnancy is contraindicated.

Dosing and Administration

As we have already explained, flukostat during pregnancy can be appointed by a doctor only if there is a threat of developing a generalized form of fungal infection with the defeat of most internal organs and tissues. If there is a high risk of generalization of the infection, the doctor prescribes the drug at a dosage of 400 mg once a day, the duration of treatment from one week or more, depending on the indications.

For prevention and with local forms of candidiasis, flukostat during pregnancy, as a rule, is not prescribed.

Can Fluxostat be Pregnant?

Flucostat is an antifungal drug that is represented by the active substance fluconazole. This substance is widely used for the treatment of candidiasis, both in women and men. Such drugs as fucis, difluzole, diflucan, mycosyst, flucoside are all synonyms for fluconazole-based flucostat.

It remains to add that all without exception preparations of fluconazole (including flucostat) are prohibited for use during pregnancy, as well as during breastfeeding. The fact that this drug actively penetrates all tissues and body fluids, including through the placental barrier. Fluconazole has a toxic effect not only on the fungal infection, but also on certain processes of the vital activity of the body, including the organism of the intra-utero growing baby.

To treat thrush during pregnancy, there are other, less toxic drugs. Flucostat can be used only with generalized candidiasis, when a fungal infection can threaten the life of a pregnant woman. In such cases, the benefits for women are assessed higher than the harm done to the child.

Flucostat in planning pregnancy

If you use flucostat in planning your pregnancy, the use of the drug should be evaluated by your doctor. It is recommended to first treat thrush or candidiasis, and only then start planning for pregnancy. If a fungal infection has caught you at the planning stage, the best solution is to postpone conception, or use other antifungal drugs that are not prohibited during pregnancy.

The fact is that the pharmacological properties of flucostat are somewhat specific: the active component of fluconazole is distributed across all tissues in the body. His excretion through the kidneys is slow, for several weeks. Remains of the substance are found in the nail tissue even after six months (!) After the end of treatment with a flucostat. Given the accumulation of the drug in the body and its slow elimination, it is recommended to carry out treatment with flucostat before planning pregnancy.

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Fluxostat in early pregnancy

Experimental studies, which were conducted at the Danish Research Institute, determined the effect of the active component of flucostat in the early stages of pregnancy. Scientists have found that the use of medications in the first weeks of pregnancy can provoke the development of heart defects in a future baby.

Unfortunately, there are often cases when a woman in an early period takes a fluokostat, not yet knowing her "position." But just in the first weeks of gestation, at the beginning of the first trimester, at the time when the heart system and fetal organs are forming, many medications are very, very dangerous.

The researchers analyzed the health indicators of children who were born between 1996 and 2011. During the experiment, it was found that those women who took flucostat in the first weeks of pregnancy or later, the statistics of the incidence of their children with congenital heart disease was three times higher .

Previous studies have already shown that the use of large doses of flucostat in the first weeks of pregnancy can cause a number of birth defects in newborns, such as defects in the musculoskeletal system, malformations of the mouth and face, etc.

In this regard, it was decided not to use fluconazole drugs during pregnancy and breastfeeding.

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Contraindications to the use of flucostat in pregnancy

Contraindication to the use of flukostata in pregnancy is, in fact, the pregnancy itself.

Flucostat refers to drugs with the assigned category of effects on the fetus by FDA-C.

What does this mean?

The Department of Medicinal Control of the US Department of Health identified a number of possible dangers to the fetus due to the use of medications by pregnant women. This list has six categories: the flucostat in this list is categorized as C. This category includes those drugs that have been experimentally tested in animals and their negative impact on the fetus has been proven. However, the same studies in humans with these drugs have not been conducted, which, on the one hand, can justify their use, but, on the other hand, this represents considerable risk for the developing child.

For this reason, specialists try to refrain from the appointment of flucostat, replacing this drug with other antifungal agents, which definitely do not carry a damaging effect on the fetus.

Side effects of flucostat in pregnancy

For a long time there were no reports of any side effects of flucostat on the fetus and pregnancy. However, at present, there is information that newborns whose mothers used uncontrolled amounts of fluconazole for three months or more found different birth defects. Of course, direct studies on this subject have not been conducted, but at the moment it is considered that the use of fluconazole (active ingredient flukostat) at a dosage of 400 mg / day can adversely affect the development of the fetus.

To the standard side effects that can appear in non-pregnant women, include the following:

• changes in taste, indigestion, attacks of nausea, yellowing of sclera and skin;
• pain in the head, dizziness, seizures;
• disorders of cardiac activity;
• allergy;
• impairment of renal function.

Overdose

If unreasonably high dosages of flucostate are used, paranoid behavior and hallucinogenic conditions may develop, and the side effects of flucostat during pregnancy may increase.

There is no special antidote for drug overdose. As a rule, use symptomatic therapy, gastric lavage, prescribe sorbent drugs (activated charcoal, sorbex, etc.). Hemodialysis or forced diuresis may be used.

Reviews of Fluxostat in Pregnancy

Before making independent conclusions, based on reviews of Fluxostat in pregnancy, it is necessary to consult with the doctor. Pregnancy is not the time for experiments on yourself and the future child, and flukostat (as well as other preparations of fluconazole) is not a drug that can be taken carelessly during pregnancy.

Pregnant women are recommended to use medicinal anti-fungal topical agents: suppositories, ointments, gels or sprays. Such medications have a local effect, almost not absorbed into the bloodstream and without adversely affecting the fetus and the course of pregnancy.

Flucostat also refers to systemic drugs that not only penetrate the blood and are carried throughout the body, but also settle in liquids and tissues, including in the reproductive organs and tissues of the embryo.

Only with the generalized course of fungal infection, with the threat of life for a woman, you can admit the use of preparations of fluconazole. In any case, flukostat during pregnancy should appoint a doctor: on its own, it is inadmissible. Moreover, if you are planning a pregnancy, then before you start taking flucostat, make sure that conception has not taken place, and during treatment use condoms.