Ointments from scars

To reduce the defect that occurs on the skin after healing of its damage (postoperative suture, cut wound, burn, etc.), an ointment is applied from the scars, a dense connective tissue that replaces the normal epidermis and differs from it by its structure. In the scar tissue, fibrillar protein collagen, consisting of glycoprotein fibers, predominates.

In addition, fibrous scar tissue can expand, forming the so-called keloids. In such cases, properly selected ointment from keloid scars can help.

[1], [2]

Release form

Let's list some names of ointments from the scars, which showed a therapeutic effect and can be used in clinical practice.

So, in order to prevent the growth of scar tissue, corticosteroid preparations such as 1% hydrocortisone ointment (other trade names - Laticort, Akortin) are prescribed. It is widely practiced to use sinaflana ointment in a keloid scar (Cinaphlan or Flucinar).

Sodium heparin belongs to the drugs of the anticoagulant group, and Heparin ointment, promoting the resorption of thrombi, is used in the complex treatment of varicose veins and superficial thrombophlebitis of the veins of the lower extremities, for resorption of various localized hematomas, removal of swelling of soft tissues, and ointment from keloid scars.

Heparin sodium is part of the gel Kontraktubeks and ointment from the old scars Kelofibraze (Dermofibraze).

To soften and reduce the scar, silicone ointment (gel) Dermatix (Zeraderm ultra) is used. This remedy is used as a fairly effective ointment for resorption of scars on the face. Cicatricial traces of acne on the face helps to reduce the ointment on the gel basis of Mederma.

Local preparations based on retinoic acid are used to treat severe forms of acne; In addition, retinoic ointment from scars can help prevent the formation of coarse scar on the site of acne.

In the process of healing of many damages, an effective ointment from the scarred Madecassol can be used - with the extract of the medicinal plant Centella Asiatica. This remedy has proven itself as an ointment from atrophic scars (that is, slightly depressed) that appear after the healing of the skin due to a violation of the synchronous formation of the granulation tissue in the wound and its epithelialization. Very often, scars of this type are formed after acne.

Ichthyol ointment from scarring is rarely used today, as there are newer and more effective means, especially since this ointment has been used and continues to be used as an antiseptic for stopping suppurative inflammation of the skin.

Exceptionally for the acceleration of the reparative regeneration of injuries, including wounds, burns and trophic ulcers, eczema and dermatitis use the Metuluracil ointment.

There is nothing to help with scars zinc ointment: it's an antiseptic, well drying the damp (nerve) inflammation of the skin with dermatitis or intertrigo. Although, if you smear with zinc ointment just jumped out a pimple, then you can get rid of it without a trace. But Clearin is not a medicinal product, it is a cosmetic cream based on Ayurvedic herbs and beeswax, recommended for caring for problem skin.

To date, Heparin and hydrocortisone ointments, as well as the drug Sinaphlan - the cheapest ointments from scars.

Although the formation of scar tissue is a physiologically determined component of the healing process, a popular alternative means - an ointment of yolks from burn scars - supposedly helps to heal a burn without scars. This preparation is prepared by evaporating in a dry frying pan the yolks of several eggs boiled in a hard-boiled egg.

[3], [4], [5], [6]

Pharmacodynamics

In the healing site of damaged skin, many actively multiplying poorly differentiated fibroblasts, which intensively produce protein components of connective tissue (collagen and elastin) and glycosaminoglycans of the intercellular matrix (hyaluronic and glucuronic acids, dermatan sulfates, etc.).

The action that Heparin ointment has on this process is due to the ability of negative-charged heparin sodium molecules to bind molecules of the intercellular fluid that have a positive charge. In addition, heparin refers to glycosaminoglycans and promotes the ordering of metabolism in the intercellular substance of the skin, containing fibrils of connective tissue (from which the scar is formed).

Topical glucocorticosteroids - Hydrocortisone ointment and ointment Sinaphlan (Flucinar) - in addition to reducing the synthesis of inflammatory mediators and blocking of mast cells, inactivate fibroblasts, reducing the production of fibrous protein of scar tissue - collagen. Thus, the use of synaplan ointment in keloid cicatricides fully justifies itself.

Silicone Ointment Dermatix (Zeraderm Ultra) affects differently: its constituent polysiloxane (oxygen-containing silicone) and silicon dioxide when applied to the skin form a very thin protective layer that retains moisture and helps to soften scar tissue.

The ointment for resorption of the scars on the face of Mederma consists of tsepalin - an extract of onion (flavonoids which inhibit the proliferation of fibroblasts) and allantoin, a product of the oxidation of uric acid, which helps to retain moisture in the matrix of the skin and facilitates the ordering of collagen fibrils in scar tissue.

The active substance of the ointment Madecassol is an extract of the medicinal plant of Centella or fungus of Asiatic, having in its composition triterpene saponins with surface and hemolytic activity. A special role is played by Asiatic acid, under the influence of which skin lesions heal faster, and fibroblasts divide more slowly, producing less dense collagen. Due to these processes, a rough scar tissue is not formed on the surface of the wound.

Retinoic ointment from scars or isotrexin contains the retinoic acid compound isotretinoin. Its inhibitory effect on the formation of the main collagen-producing skin cells of fibroblasts with a simultaneous positive effect on epithelization in the upper layers of the damaged skin was noted. And this is due to the participation of retinoic acid in the process of differentiation of young fibroblasts into collagenoblasts, myofibroblasts and fibroblasts, the latter acting as phagocytes, destroying excess collagen. Therefore, topical agents with retinoic acid are used both for injecting into the scar tissue and for ointment from keloid scars. See also - Treatment of keloid scars.

Improves the trophic and water balance of skin cells and intercellular matrix ointment from old scars Kelofibreze based on urea and heparin.

[7], [8], [9]

Dosing and administration

Any ointment from scarring is applied to its surface with a very thin layer: Heparin and hydrocortisone ointments, Dermatix and retinoic ointment from scarring - twice a day;

The use of synaflane ointment with colloid scar allows three times within 24 hours (lightly rubbing into scar tissue); Synflane can not be applied to the skin!

Ointment for resorption of scars on the face of Mederma can be applied up to four times a day (duration of application varies from two to six months).

According to the official instructions, Kelofibraze is recommended to be used two to three times a day, followed by a gentle massage of the treated area. The course of treatment can last up to six months.

[15], [16], [17], [18], [19], [20]

Use of the ointments from scars during pregnancy

Data on the use of ointments from scars Dermatics, Mederma, Kelofibraz during pregnancy are not available.

Retinoic ointment for pregnant women is prohibited.

Heparin ointment is allowed for use by pregnant women only if it was prescribed by a doctor, having previously examined the patient's blood to the level of platelets.

Preparations of the group of glucocorticosteroids - Hydrocortisone ointment, Sinaphlan (Flucinar), etc. - in pregnancy, they are appointed in exceptional cases, since they can lead to serious disturbances in the work of the adrenal glands of the unborn child.

Contraindications

Contraindications to the use of the above mentioned means include:

• Heparin ointment - violations of the integrity of the skin and poor blood coagulability;
• Hydrocortisone ointment and Sinaphlan - purulent skin inflammations and manifestations, fungal diseases, skin tuberculosis;
• Dermatrix - infections and skin lesions;
• Mederma, Kelofibraze - hypersensitivity to drugs;
• Retinoiemuyu ointment is best not to use with kidney and / or liver deficiency, pancreatic diseases and serious problems with the heart.

[10], [11], [12], [13], [14]

Side effects of the ointments from scars

Heparin ointment: skin hyperemia, hives, itching;

Hydrocortisone ointment and Sinaphlan: dry skin, burning, itching, acne, stria, discoloration, the appearance of a vascular network;

Dermatix: skin hyperemia after ointment application;

Mederm and Kelofibraze: redness and burning of the skin;

Retinoic ointment: redness, excessive dryness and peeling of the skin.

Overdose

According to manufacturers, an overdose of these ointments was not fixed or, in principle, impossible.

[21], [22], [23], [24]

Interactions with other drugs

Ointments from Dermatrix scars, Mederma, Kelofibrease, Hydrocortisone Ointment and Sinaphlane should not be used concomitantly with any other external remedies.

In addition, Heparin Ointment is incompatible with the administration of NSAIDs, tetracycline and antihistamines, and Retinoic Ointment with tetracycline and corticosteroids.

Storage conditions

Retinoic ointment from scars should be stored at a temperature of + 5-10 ° C; Heparin ointment - at + 12-15 ° C; Hydrocortisone ointment, Sinaflan, Dermatix, Mederma, Kelofibraze - up to + 25 ° C.

[25],

Shelf life

Shelf life: Dermatrix - 5 years, Heparin ointment - 3 years, Hydrocortisone ointment, Sinaphlan, Retinoic ointment, Mederma, Kelofi-abase - 2 years.

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