Xenical for weight loss

Everyone, especially women, gets frustrated because of excess weight. You can deal with it in different ways. Someone chooses a diet, someone doing sports, someone takes special medications. Very popular among users is to date, "Xenical" for weight loss. It is produced by a Swiss company. As a rule, it is recommended to patients who have obesity as a result of diabetes mellitus, hypertension or atherosclerosis.

Indications for use

The drug is most often used:

1. In combination therapy: together with hypoglycemic agents (insulin, metformin). This helps cure type 2 diabetes, which is accompanied by excess weight.
2. For long-term therapy: helps to get rid of obesity (even if patients have risk factors due to excess weight).

How does Xenical work for weight loss?

The main active component of the drug "Xenical" for weight loss is orlistat. Due to the fact that this agent blocks almost 30% of all fats are excreted from the body without being absorbed. Feeling the approach of "difficult times", the body begins to expend its supplies.

According to various sources, thanks to "Xenical" the weight of a person is reduced by 20-30%. The drug has many advantages. One of the most important is the fact that it is not absorbed into the blood, so there is no addiction and negative impact on the organs.

Pharmacokinetics

Carrying out studies on volunteers who did not differ in excess weight, experts noticed that "Xenical" had practically no effect on the body. Quite often orlistat can be detected in small amounts in the plasma. Cumulation is absent, so you can say that the minimum amount of the drug is absorbed.

Due to poor absorption of the means, it is rather difficult to determine Vd. The binding of orlistat with plasma proteins occurs by 99%. Sometimes a small amount of active substance can penetrate into the red blood cells.

The process of exchange orlistat passes in the stomach (in particular, on its walls). The amount of the drug that is not absorbed is excreted through the feces (97% of the dose that was taken and 83% of pure orlistat).

Dosing and Administration Xenical for weight loss

To "Xenical" did not bring trouble, you need to know how to apply it correctly. First of all, you need to pay attention - if you want to throw off just a couple of kilograms, this tool does not suit you. Better pay attention to dietary supplements or other similar drugs.

In addition, "Xenical" for weight loss is part of the combination therapy. The patient must first go to a special low-calorie diet, reduce fat intake, and then take this remedy. For example, if in your daily menu the calorific value was about 2000 kcal, then you can consume only 67 g of fat, evenly distributing them for the whole day. Therefore it is necessary to consult a specialist.

Note that "Xenical" for weight loss should be taken only under the careful supervision of a doctor, especially if you suffer from diabetes, kidney stones.

The therapy lasts two months. Every day the patient takes one capsule of the drug before meals (the number of capsules depends on the number of meals). But, if you neglected fats during any reception, then the capsule can not be drunk. Thus, the average dosage is one to three capsules per day. If you forgot to drink the drug, do it later is not necessary.

Due to the fact that "Xenical" does not work well for the absorption of fat-soluble vitamins, it is necessary to add to the therapy the use of multivitamin complexes. They need to be taken two hours after the drug is consumed.

[5], [6]

The use of Xenical for weight loss during pregnancy

This drug is in the category B. That is, in the course of studies in various animals, no risks to the fetus were found, but clinical trials were not conducted. At the same time, several side effects were noted, which, however, did not lead to complications in fetal development.

Pregnant women "Xenical" are not prescribed, because there are no necessary clinical data on the risks.

Contraindications for use

Of course, all drugs that help to reduce excess weight, have contraindications. "Xenical" was no exception. It can not be accepted:

1. Patients on cholestasis.
2. Those who are under 18 years of age.
3. Patients with chronic malabsorption syndrome.
4. When intolerance of its components, in particular, orlistat.

[1], [2], [3], [4]

Side effects

Usually side effects from the application of "Xenical" arise in the gastrointestinal tract, since the drug prevents the absorption of fats in the intestine. Many patients after the use of the remedy note the appearance of oily discharge from the anus, gases with a small amount of secretions, steatori, liquid stool and frequent urge to defecate, discomfort of varying intensity in the abdominal region (sometimes with pain), flatulence.

It should be noted that when the amount of fat that enters the body with food increases, so does the possibility of side effects. Their frequency also increases. Prior to the appointment of patients' funds, it is necessary to inform about all the negative consequences and tell what to do in order to overcome them (observe a special diet).

As a rule, patients suffer from side effects only in the first 3 months of admission. Often they are so insignificant that patients do not notice them. More frequent effects are: discomfort and pain in the rectum, the appearance of "soft" stool, swelling, inability to restrain defecation, problems with gums and teeth. More common are headaches, infectious diseases, weakness, dysmenorrhea and unreasonable anxiety.

Overdose

Carrying out clinical studies, experts noticed that even with an increased dose of the drug (800 mg per day), there are no undesirable negative effects. Even if people who are overweight, increase the dose of intake (240 mg three times a day with the duration of therapy in six months), there are no significant negative consequences.

If the overdose was too pronounced, you need to monitor the condition of the patient within 24 hours.

Interactions with other drugs

Biguanides, amitriptyline, digoxin, atorvastalin, fibrates, losartan, fluoxetine, oral contraceptives, phenytoin, pravastatin, phentermine, nifedepine, warfarin, alcohol, sibutramine do not interact with orlistat. But in some cases, you need to monitor the patient's condition in addition.

"Xenical" with some vitamins (tocopherol, cholecalciferol, betacarotene) can reduce their absorption. If the patient simultaneously takes cyclosporine, the concentration of the latter decreases in plasma. When taking this drug with amiodarone, systemic exposure of desethylamiodarone and amiodarone decreases. Sometimes convulsions may develop with the simultaneous administration of orlistat and medications for the treatment of epilepsy.

Storage conditions

It is recommended to store the drug in a place inaccessible to children in a wet place with a temperature of not more than +25 degrees.

More information about storage conditions can be found in the instruction, which is necessarily added to the drug.

Shelf life

The drug should not be used after the expiration date. He is three years old.

Diet with Xenical for weight loss

Usually when taking "Xenical" for weight loss does not require any special diet. But in the menu it is necessary to include only products with a low amount of fat. For example, you can make such a daily diet:

1. Instead of bacon boil the chicken breast (remember that it should be eaten without skin).
2. Cook the mashed potatoes. Do not give milk and butter.
3. Be sure to add fresh vegetables and fruits.
4. Add yogurts, yogurt and cottage cheese with a small amount of fat.

[7], [8], [9], [10]

Analogues Xenical for weight loss

Today, some manufacturers produce analogues of "Xenical" for weight loss. The most popular are:

1. Allie. It is based on the active substance - orlistat. He loves pancreatic and gastric lipases. This helps reduce the absorption of fats from the gastrointestinal tract.
2. Orsotene. The composition of the drug is not only Orlistat, but also Orsotene (these are semi-finished products). It has a long action.
3. Xenalten. Active active ingredient is orlistat. It is often prescribed if it is necessary to maintain a positive result after weight loss.

[11], [12], [13]