Fenotropil for weight loss: how to take and the results

In the pharmacotherapy of obesity, Fenotropil can be used to lose weight, that is, to reduce excess body weight. Although this drug belongs to the psychoactive drugs nootropic series, designed to improve the functions of the brain and the central nervous system. ATX code is N06BX.

Other trade names are: Fonotracetam, Entrop, Carphedon.

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Indications of the phenotropil for weight loss

The main indications for the use of Fentropil include:

• associated with senile dementia cognitive impairment;
• Alzheimer's and Parkinson's;
• memory impairment and decreased ability to learn different etiology;
• increased fatigue and reduced stress resistance;
• depression and neurotic states;
• multiple sclerosis;
• cerebral-vascular disorders and cerebral ischemia;
• obsessive-compulsive disorder of the psyche, mild form of schizophrenia;
• focal epilepsy;
• alimentary obesity;
• alcoholism.

Since Phenotropil can increase physical endurance and performance, it is popular with bodybuilders. For the same reason, this drug is banned by the World Anti-Doping Agency for use by professional athletes.

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Release form

The form of the release of Fentropil - tablets of 0.1 g.

Pharmacodynamics

Like all nootropic drugs of the group of ratsetam, the pharmacodynamics of phenothropyl is due to the active substance, which is a derivative of 2-pyrrolidone, a heterocyclic nitrogen compound.

By activating the ionotropic receptors (NMDA and AMPA) of the L-glutamate neurotransmitter on the membranes of the pre and postsynaptic neurons of the brain, the drug promotes an increase in the reuptake of L-glutamate and reduces its excitotoxicity, preventing damage and apoptosis of nerve cells. Thus, Phenotropil helps to increase the stability of brain cells and has a neuroprotective effect.

Phenotropol blocks the production of the enzyme acetylcholinesterase, which increases the level of acetylcholine in the presynaptic depot and the amount of N-cholinergic receptors, and this positively affects the activity of nerve signaling in the central nervous system.

In addition, the drug enhances the synthesis of dopamine in the brain, stimulating and dopaminergic neuromedication, thereby increasing cognitive function of the brain and mood.

In turn, a higher level of dopamine stimulates the release of norepinephrine, which potentiates pulses in the adrenergic synapses, facilitating the cleavage of glycogen (which increases the release of glucose into the blood), as well as the breakdown of fats (which activates thermogenesis). As a result of the cascade of biochemical interactions, metabolic and energy processes in the body are accelerated.

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Pharmacokinetics

Fentropil is rapidly absorbed into the digestive tract, and its maximum concentration in the blood plasma is noted one hour after ingestion; the level of bioavailability of the drug is almost 100% with penetration of the active substance into the tissues of all internal organs (also penetrates through the BBB).

In the body, Phenotropil is not transformed and does not form metabolites; more than half of the drug is eliminated by the kidneys, the rest - through the intestine. The average half-life is about 4-4.5 hours.

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Dosing and administration

The method of application of this drug is oral, and the dose of Fentropil for weight loss for obesity is 1-2 tablets (0.1-0.2 g) once a day. It is recommended to take the pill in the morning. Duration of use depends on the degree of obesity and the condition of the patient, but the usual course of taking Fentropil is 4-5 weeks.

Contraindications

Among the contraindications to the use of this drug, in addition to individual hypersensitivity to its components, the official instruction notes: hemorrhagic stroke, Huntington's chorea, pronounced kidney and liver failure, childhood and pregnancy. Thus, the use of phenotropil for weight loss during pregnancy is strictly prohibited.

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Side effects of the phenotropil for weight loss

The use of this drug to improve the functions of the brain, as well as the use of Fenotropil for weight loss can cause side effects in the form of insomnia, headaches and dizziness, skin flushing and hot flushes, increased blood pressure, a state of psychomotor agitation, tremor and muscle cramps , dry mouth, nausea, vomiting, incontinence of urine and feces, loss of appetite.

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Overdose

Overdosing of the drug leads to an increase in its side effects and requires symptomatic treatment.

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Interactions with other drugs

Fenotropil for weight loss increases the effect of tranquilizers, psychostimulants of any pharmacological groups, drugs with thyroid-stimulating hormones, as well as anticoagulants of indirect action.

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Storage conditions

Fentropil should be stored in a dry place, protected from sunlight, at normal room temperature.

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Shelf life

Shelf life is 36 months.

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Reviews

Real reviews of those who lose weight and the results of using Fenotropil for getting rid of excess weight is difficult to distinguish from "comments on advertising rights", so you should not rely on them.

And doctors' reviews mainly concern the fact that nootropic drugs should not be considered as a first-line treatment for weight loss. They can stir up metabolism and for a very short time increase fat burning in the body, and (due to side effects) suppress appetite.

But Phenotropil is unsafe for long-term use and can lead to addiction. And it is not uncommon for cases when, after the cessation of its reception, a brutal appetite appears. Therefore - to avoid health problems - it is better to consult a doctor, whether you should use Fenotropil for weight loss.