Medical expert of the article
New publications
Preparations
Low molecular weight hyaluronic acid
Last reviewed: 08.07.2025

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Low molecular weight hyaluronic acid is produced (0.25-0.45) from high molecular weight and has such a low weight that it easily penetrates into all layers of the skin, perfectly moisturizes it, and stimulates collagen production.
In recent years, the popularity of hyaluronic acid has increased greatly. It is successfully used in cosmetology. It is believed that hyaluronic acid has a unique effect on the skin, starting its regeneration processes and literally giving a second youth. Hyaluronic acid is a polysaccharide that is found in the tissues of the human body. The largest amount of hyaluronic acid is found in cartilage, eyes and skin. This unique substance that fills the intercellular space is responsible for the preservation of cell structures. Over the years, the body's production of hyaluronic acid is significantly reduced, the skin suffers from a lack of moisture, loses tone, elasticity, firmness, and the skin ages rapidly.
However, due to an unhealthy lifestyle, alcohol abuse, and smoking, a lack of hyaluronic acid can also occur in young girls under 30 years of age.
Low molecular weight hyaluronic acid in cosmetology
Low-molecular hyaluronic acid has been used in cosmetology for a long time and very successfully. This substance is biologically fermented, of non-animal origin. Together with the hydrated shell, low-molecular hyaluronic acid supplies water to all internal layers of the epidermis and the stratum corneum.
Low-molecular hyaluronic acid interacts perfectly at the cellular level with the epidermis and dermis. In addition, this unique substance promotes the production of enzymes that are responsible for maintaining the integrity of skin barriers and protects the skin from harmful solar radiation.
Cosmetologists actively use low-molecular hyaluronic acid, as it has proven itself well. This substance is used in biorevitalization, when hyaluronic acid is introduced into the skin using electroporation, ion-, laser- or electrophoresis or a mesoroller.
To fill deep wrinkles, correct the oval of the face, change the shape of the lips, fillers based on hyaluronic acid are injected. The viscous structure of the fillers gives the effect of moisturizing and filling.
Low molecular weight hyaluronic acid is included in moisturizing creams and emulsions.
Cosmetics with low molecular weight hyaluronic acid
Cosmetics with low-molecular hyaluronic acid are very popular among women all over the world, as they literally return the skin to a second youth. Low-molecular hyaluronic acid is most often included in emulsions and moisturizing creams.
By the way, in recent years, pharmacies have started to sell products that contain low-molecular hyaluronic acid and, of course, vitamin C, which significantly enhances the effect of the acid. Cosmetologists note that with regular use of these additives, the effect of using creams and emulsions with hyaluronic acid is simply amazing, it increases more than 7 times!
In addition, supplements with hyaluronic acid for oral administration improve the condition of the skin of the face, joints and ligaments, vision and increase immunity, because hyaluronic acid, as we know, is contained in all tissues of the human body.
[ 4 ]
Cream with low molecular weight hyaluronic acid
Cosmetics based on low-molecular hyaluronic acid are very popular. This substance is included in emulsions and moisturizing creams. The fact is that creams that contain low-molecular hyaluronic acid act both in the deep layers of the skin and on its surface, forming a thin film, which in turn attracts water from the air like a magnet, moisturizing the skin.
In addition, the active substances that are part of the cream based on hyaluronic acid remain in all layers of the skin for a long time.
Cosmetologists note that cream with low-molecular hyaluronic acid works wonders on the skin. This substance moisturizes, regenerates the skin, and also has a bactericidal, antiviral and wound-healing effect.
Ultrasonic hyaluronoplasty with low molecular weight hyaluronic acid
This method is very popular, it is rightfully considered safe and natural. Ultrasonic hyaluronoplasty with low-molecular hyaluronic acid is done in every respectable beauty salon and plastic surgery clinic. This procedure is an excellent alternative to non-injection biorevitalization.
How does ultrasound hyaluronoplasty with low-molecular hyaluronic acid work? Using ultrasound phonophoresis, a special concentrated gel with 2% low-molecular hyaluronic acid is injected into pre-cleaned facial skin.
The result is simply amazing! The skin is moisturized, fine wrinkles disappear, the skin color improves significantly, an instant lifting effect occurs, enlarged pores are narrowed, and skin tone improves. To achieve the maximum effect, it is advisable to conduct several sessions of ultrasound hyaluronoplasty with low-molecular hyaluronic acid. The effect is noticeable after the first procedure.
Cosmetologists recommend this procedure to anyone with dry, aging skin, severe dehydration of the facial skin, or decreased skin elasticity.
Low Molecular Weight Hyaluronic Acid Reviews
On cosmetologist forums, social networks and women's forums, there are often discussions about the properties of using low-molecular hyaluronic acid. In 95% of cases, "hyaluronic acid" receives only positive, even enthusiastic reviews.
Women who have used creams and emulsions based on low-molecular hyaluronic acid note that the skin condition improves after a week of using cosmetics. Fine wrinkles are smoothed out, the tone and color of the skin improves, it is perfectly moisturized throughout the day and has a healthy color.
Injections with hyaluronic acid, as well as ultrasound hyaluronoplasty with low molecular weight hyaluronic acid, are very popular among women who take care of themselves and maintain the youthfulness of their facial skin.
Attention!
To simplify the perception of information, this instruction for use of the drug "Low molecular weight hyaluronic acid" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.