Paternal causes of miscarriage
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Paternal causes of miscarriage are less important than maternal ones, except for chromosomal pathology. Nevertheless, according to many researchers, the husbands of women with habitual miscarriage have a high percentage of spermatogenesis disorders: oligospermia, polyspermia, teratospermia and leukocytospermia.
According to the research, when examining married couples with a history of miscarriages in the content of proteins in the semen by the method of immunodiffusion analysis, it was revealed that in men there is a marked decrease in fertility proteins. Thus, the α2-microglobulin of fertility (AMGF), produced by seminal vesicles, is practically halved compared to the control group: 21.6 ± 1.8 and 40.6 ± 2.7 μg / ml, respectively. With the lack of AMGF in the ejaculate, migration of spermatozoa in the female genital tract is disturbed, which can lead to disturbances in the process of fertilization and formation of an inferior fetal egg. A significant decrease in the level of PAMG-2 (placental alpha-2-microglobulin in sperm up to 16 μg / ml and below) is noted as a result of a low content of PAMG-2, an "aging" of the spermatozoa occurs, which, when fertilized, leads to the formation of a defective fetal egg.
The content of salivary globulin (SSH) produced by the testes is increased in comparison with the control group (57.9 ± 8.9 and 17.7 + 2.7, respectively). The elevated level of GCC explains the fact that, being resistant to the action of proteolytic enzymes, this protein can perform its function in inflammatory foci. Inflammatory processes in men in a married couple with miscarriage is very common. Thus, according to studies, chronic prostatitis is detected in 38.8% of men, chronic urethritis - in 7,7%.
According to studies, inflammatory changes in the form of prostatitis, urethritis, varicocele, violations of spermatogenesis are observed in 42% of men in a couple with miscarriage. Therefore, when examining a married couple, it is necessary to examine the spermogram, and in the detection of pathology, refer to the andrologue for more accurate diagnosis and treatment.
It is believed that the chronic alcoholism of the father is associated with the interruption of pregnancy.
[