Since 1970, natural prostaglandins have been used as therapeutic agents in obstetric and gynecological practice for the maturation of the cervix and premature termination of pregnancy, with the aim of induction and rhodostimulation.
In recent years, in clinical practice, widespread use of muscle relaxants of central action. Due to the fact that, in contrast to peripheral action relaxants, they do not disable spontaneous breathing, nor do they adversely affect the cardiovascular system and other vital organs and systems.
Promedol (trimeperidine hydrochloride). Promedol, as is known, is a synthetic substitute for morphine and has a pronounced analgesic effect. Reduction of pain sensitivity under the influence of promedol develops after subcutaneous injection after 10-15 minutes.
Theoretically, any substance that in a proportionate dose weakens the spasm of smooth muscles caused by acetylcholine can be used as an antispasmodic. In practice, far from all anticholinergic substances are used as antispasmodics.
Gangleron. The drug has ganglioblokiruyuschim, central holinoliticheskim, spasmolytic and anesthetic action. Gangleron is a persistent substance that slowly hydrolyzes in the body. It dilates the vessels, causing an antihypertensive effect.
Clopheline (hemiton, catapresane, clonidine) - has a pronounced hypotensive effect. Clopheline is used in therapeutic practice for the treatment of hypertension. It was found that with late toxemia of pregnant women, the level of catecholamines in the blood increases, and the use of clonidine leads to hypotensive, sedative and small diuretic effects.
Levodopa. Dioxyphenylalanine (DOPA or DOPA) is a biogenic substance formed in the body from tyrosine and is a precursor of dopamine, which in turn is converted into noradrenaline and then into adrenaline.
Excitation of muscular cholinergic receptors of myometrium causes an increase in hydrolysis of phosphoinositides, activation of phospholipase A2, activation of protein kinase C, reduction.
Currently, there are a number of highly effective domestic and foreign antispasmodics. At the same time, from an infinite number of different drugs studied and applied over the past few years, only a few who have stood the test of wide practice on the basis of their effectiveness, harmlessness for both the mother and the child and the ease of execution can be offered now.
When a woman in labor arrives in the maternity department and the phenomena of feelings of fear, anxiety, uncertainty, mental stress or emotional excitement, tranquilizers - trioxazine in a dose of 300-600 mg orally, or diazepam in a dose of 5-10 mg, or phenazepam 0.0005 g in combination with spasmolithine, which also has a sedative and spasmolytic effect.