The prolonged phase of deceleration is characterized by an increase in its duration in primiparas by more than 3 hours, in repetitive ones - by more than 1 hour. Under normal conditions, the average duration of the deceleration phase is 54 minutes in primiparas, and in 14 months - in multi-generators.
Progressive advancement of the presenting part of the fetus in the cavity of the small pelvis (lowering) is an important sign of normal delivery. Lowering usually begins with the maximum opening of the cervix and is easily traced in the phase of deceleration and especially in the second stage of labor. In some parturient women, subsidence is completely absent.
The main biological effect of oxytocin in mammals, both in vivo and in vitro, is to stimulate contraction of the uterine muscles and myoepithelial cells surrounding the alveoli of the mammary gland.
The experimental and clinical substantiation of the use of beta-adrenomimetics, in particular of isadrin, in the complex therapy of miscarriage is carried out. Pregnant women were prescribed either only Isadrin or Isadrin in combination with spasmolytic or with no-shp. Iazrin was given in the form of tablets 0.5-0.25 mg 4 times a day.
Since 1970, natural prostaglandins have been used as therapeutic agents in obstetric and gynecological practice for the maturation of the cervix and premature termination of pregnancy, with the aim of induction and rhodostimulation.
In recent years, in clinical practice, widespread use of muscle relaxants of central action. Due to the fact that, in contrast to peripheral action relaxants, they do not disable spontaneous breathing, nor do they adversely affect the cardiovascular system and other vital organs and systems.
Promedol (trimeperidine hydrochloride). Promedol, as is known, is a synthetic substitute for morphine and has a pronounced analgesic effect. Reduction of pain sensitivity under the influence of promedol develops after subcutaneous injection after 10-15 minutes.
Theoretically, any substance that in a proportionate dose weakens the spasm of smooth muscles caused by acetylcholine can be used as an antispasmodic. In practice, far from all anticholinergic substances are used as antispasmodics.
Gangleron. The drug has ganglioblokiruyuschim, central holinoliticheskim, spasmolytic and anesthetic action. Gangleron is a persistent substance that slowly hydrolyzes in the body. It dilates the vessels, causing an antihypertensive effect.
Clopheline (hemiton, catapresane, clonidine) - has a pronounced hypotensive effect. Clopheline is used in therapeutic practice for the treatment of hypertension. It was found that with late toxemia of pregnant women, the level of catecholamines in the blood increases, and the use of clonidine leads to hypotensive, sedative and small diuretic effects.