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Genetic tests will unlock the mystery of human longevity
Last reviewed: 02.07.2025
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To date, genetic scientists have managed to discover sixteen genetic variants that determine human life expectancy.
Among these variants, there are three genes that are associated with longevity.
Probably most of us would like to know about our potential life expectancy.
According to statistics, the average American lives 79 years. The main factors leading to death are cardiovascular pathologies, oncology and pulmonary obstruction. But if such diseases are eliminated, how many years can a person live?
Dr. Kutalik and his colleagues carefully analyzed information collected on more than one hundred thousand people. This information was compared with common single-nucleotide polymorphisms that had a clear connection with complex age-related pathologies. As experts point out, one in ten people have genetic markers that determine the degree of life expectancy reduction. Inheriting one of the gene variants reduces the probable life expectancy by about seven months.
Unfavorable single nucleotide polymorphisms are involved, for example, in the development of alcohol or drug addiction, senile dementia. Low expression of the genes RBM 6, SULTA 1, CHRNA 5 indicates a high probability of living a long life.
Scientists have conducted experiments on animals. It was found that the active gene CHRNA 5 is responsible for the passion for smoking. And everyone knows that smoking is a factor in the development of cancer and pulmonary obstruction, which can significantly shorten life. Experts insist: if you have this genetic variant, beware of nicotine!
"We found that rodents with reduced RBM 6 expression in the brain have a longer lifespan than other rodents. Interestingly, gene expression also influences eating behavior, controlling hunger. Moderation in food consumption is the key to good health and longevity," comments Dr. Robinson Reshavi, representing the Swiss University of Biological Informatics. Scientists were able to establish a relationship between the molecular mechanism of longevity in rodents and humans: at the same time, an extremely large number of common points were found.
At the same time as this discovery, Swiss specialists created a new successful program for determining genetic factors of longevity. The Association of Genetics and Biological Informatics expects to present updated markers and test programs soon.
Probably, in a couple of years, any of us will have the opportunity to test ourselves for longevity: to assess our vulnerabilities and chances for a long life. In this case, instead of general preventive recommendations, the doctor will be able to give individual advice based on the test results.
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