Scientists have proved that for each drug should have their own hours of admission
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
In one of the educational institutions of Pennsylvania, experts made an interesting discovery, as it turned out, throughout the day in the human body there are two main points that affect the condition of tissues. In their work, scientists analyzed the work of DNA and cells of 12 animal tissues and revealed significant changes that occurred early in the morning and in the evening.
As scientists believe, the changes that occur can affect the effectiveness of medicines, so when medications are prescribed, medics need to take this moment into account.
Circadian rhythms or biological (internal) human clock affect many factors, in particular, attention, mood, endurance, and even the likelihood of a heart attack. Occurring in the body, cyclic fluctuations affect the biological processes that are associated with the change of day and night.
During the experiment, specialists periodically (every 120 minutes) analyzed samples of the cerebellum, skeletal muscles, lung muscles, hypothalamus, heart, brown and white fat, brainstem, aorta, adrenal gland, lung, kidney.
As a result, they managed to establish that during the day the activity of almost half of the genes, which are associated with the production of protein, is changing. In this case, different patterns of activity were observed in different tissues and in different genes. The most dynamic changes occurred in the liver, which employs more than three thousand genes (642 genes work in the hypothalamus), and most drugs are metabolized in the liver.
This study once again confirmed the importance of observing medication hours, for example, statins that help reduce cholesterol, it is better to take in the evening, since the cholesterol blockade most often occurs precisely at night.
Circadian rhythms alternate between the period of sleep and wakefulness of the body, so a person's internal clock can get lost when changing the time zone, especially during a sharp transition. Mathematicians from the University of Michigan have developed a special mobile application that in a short time will help to adapt the body to a new time zone.
After lengthy research, the specialists presented an application called Entrain, which develops the schedule in the first days after arrival. For example, according to the schedule, you need to go for a walk at five o'clock in the morning, and go to bed at seven o'clock in the evening, but despite the fact that the recommendations of the application at first glance are a bit strange, following them you can adapt to the new conditions very quickly.
For example, when flying from New York to London, where the difference in time is five hours, the application offers a schedule in which the body will return to normal within three days. According to the schedule compiled by Entrain on the first day the morning should begin at 7-40, and at 9 pm come "night", i.e. The program is recommended at this time to go to bed. The next day the program recommends waking up at 6-20 in the morning, and at 7-40 pm there should be a "dark time", ie, if necessary, it is necessary to artificially darken the room. On the third day, the rise is scheduled at five in the morning, and the "night" should come at 7-20 pm. In this case, it is not necessary to go to bed at the specified time, you just have to try to clearly alternate the regime of day and night.
If there was a need to go out in the evening, the program recommends wearing glasses with pink glasses that block blue light. In some cases, the program on the contrary recommends that you turn on the bright light at night, thereby "simulating" the day.
As the scientists say, following the recommendations of the program is quite difficult, but they actually work. Part of the calculation of the program is based on calculations when the body temperature of a person is reduced, usually a couple of hours before awakening.
Also, experts recommend refusing to eat food during the flight, and then, to follow the schedule of food intake, compiled by the program, which will speed up the process of rebuilding the body for a new time.
[1],