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Natural plant substance prevents the development of breast cancer
Last reviewed: 23.04.2024
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The natural plant substance phenethyl-isothiocyanate (PEITC) prevents the development of tumors in the mammary gland in GM mice, "awarded" progressive breast cancer, similar to the human.
Previously PEITC demonstrated its effectiveness as a chemical preventive in mice with colon, intestine and prostate cancer, initiating apoptosis (cell death).
To test the efficacy of PEITC on mammary tumors in rodents, the staff of the Cancer Institute at the University of Pittsburgh (USA) kept the animals on two types of food for 29 weeks: on a control diet and on the stern with the addition of phenethyl isothiocyanate. In the course of the experiment, histopathological examinations were performed, tumor sizes were measured, and apoptosis, cell proliferation (cell division), and neoangiogenesis (formation of blood vessels) were assessed.
It was found that the 29-week application of PEITC is associated with a decrease in carcinoma of the breast, the size of which exceeds 2 mm, by 56.3%. And although the plant substance failed to provide complete protection against carcinogenesis (the formation and development of a malignant tumor), suppression of tumor progression was observed in mice with PEITC-diet.
Since research using preventative chemicals requires a lot of time and money, the authors believe that the discovery of biomarkers is very important for the clinical development of promising cancer prevention drugs. The research, in their opinion, allowed to identify certain biomarkers, which can be useful in future clinical experiments.
Carcinoma (other Greek, καρκίνος - "crab", -ωμα from ὄγκωμα - "tumor"), cancer is a kind of malignant tumor that develops from cells of epithelial tissue of various organs (skin, mucous membranes and many internal organs).
The incidence of malignant tumors is continuously growing. Annually in the world about 6 million new cases of malignant tumors are registered. The highest incidence among men was in France (361 per 100,000 population), among women in Brazil (283.4 per 100,000). This is partly due to the aging of the population. It should be noted that most tumors develop in people older than 50 years, and every second cancer patient is over 60 years old. The most common prostate gland and lungs in men and breast cancer in women. Death from cancer is the world's second largest after cardiovascular disease
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