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Early menopause is fraught with the development of an aneurysm in the brain
Last reviewed: 23.04.2024
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The data obtained by the scientists confirm the previously stated hypothesis that the pathogenesis of cerebral aneurysm is associated with fluctuations in the level of estrogen.
A team from the Rush University Medical Center Medical Center conducted a retrospective analysis of the case histories in a contraceptive and reproductive health research (CARES) study funded by the United States National Institutes of Health (NIH). 76 cases of cerebral aneurysm development in postmenopausal women were analyzed. It is shown that the risk of developing aneurysms is inversely proportional to the age at the onset of menopause - the earlier menopause begins, the higher it is. In general, the later age of the onset of the menopausal period reduced the risk of aneurysms by 21% (p-0.046).
The article published by the authors of the study in the Journal of Neuro-Interventional Surgery also indicates that every four additional years of menopause delay reduced the risk by about the same 20-21%. However, in this case, we can only talk about the trend, since the differences between the two study groups of patients were not statistically reliable.
It is known that in detecting intact brain aneurysms, the standard approach to treatment is to stop smoking and prescribe drugs that regulate pressure. Surgical intervention can reduce the risk of cerebral hemorrhage, but does not affect the pathogenesis of the disease. The data obtained by the scientists confirm the previously stated hypothesis that the pathogenesis of cerebral aneurysm is associated with fluctuations in the level of estrogen. This assumption is also confirmed by the fact that in patients who have ever used hormone replacement therapy, the risk of aneurysms decreases.
The authors of the work, led by the candidate of medical sciences Michael Chen (Michael Chen) hope that their study will contribute to the development of alternative therapeutic approaches to the treatment of cerebral aneurysms in the future.
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