Human hair passes through three phases of development, smoothly changing from one to another: anagen (growth phase), catagen (phase of regressive changes) and telogen (rest phase). The duration of each phase depends on a whole complex of features: localization, hair length, sex, age, race and deterministic genetic characteristics.
The prognosis of diffuse (symptomatic) alopecia is favorable in those cases when it is possible to establish the cause of hair loss and eliminating it. Usually when interviewing a patient, it is easy to find out the cause of the acute onset of alopecia (childbirth, infectious diseases, myocardial infarction, blood loss, starvation, cytostatic and radiation therapy, and many others.
Daily hair loss (up to 100) evenly over the entire surface of the scalp is a physiological process; The follicle, which has lost hair, re-enters the anagen phase and alopecia does not develop.
Anagen hair loss is an excessive hair loss in the anagen phase, which is observed in patients with malignant neoplasms as a reaction to cytostatic and radiation therapy. Hair loss begins suddenly, 4-10 days after exposure, and can lead to total baldness.
We should dwell in more detail on the relationship of hair loss with the content of trace elements in the human body. The doctrine of microelementoses (MTOZs) as diseases, syndromes and pathological conditions caused by excess, deficiency or imbalance of microelements in the human body is a huge new multidisciplinary scientific direction
Many drugs of systemic action, prescribed for various reasons, can cause common hypertrichosis as a side effect, and also positively affect the hair condition on the scalp (benoxaprofen, cyclosporin A, PUVA), but their targeted systemic use in conventional baldness is unreasonable, for undesirable complications.
Experience has shown that some retinoids can influence the speed of hair growth, extending the anagen phase and shortening the telogen phase. These drugs independently stimulate hair growth, and also increase the clinical effectiveness of minoxidil.
Tricomin, a copper-peptide complex designed for topical application, was tested in 18 men with type V (according to J. Gamilton) of normal alopecia. Twice a day for 6 months, 2% and 10% gel were applied to the areas of baldness. In patients who used 10% gel with tricomin, more active hair growth was noted.
In connection with the establishment of the key role of androgens in the development of normal baldness and manifestations of the syndrome of hyperandrogenism, in the treatment of these diseases substances with antiandrogenic properties are used.
The method consists in transplanting androgen-resistant hair from the lateral and occipital areas of the head to areas of hair thinning or alopecia. Each implant (graft) contains from 1 to 5 hair bulbs (follicles).