Signs of preeclampsia linked to increased risk of early-onset dementia
Last reviewed: 14.06.2024
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People with preeclampsia have an increased risk of early-onset dementia, according to a study published in JAMA Network Open.
Valérie Olie, PhD, of Santé Publique in Saint-Maurice, France, and colleagues obtained data from the nationwide prospective Conception study, which included all births in France after 22 weeks of pregnancy between January 1, 2010, and December 31, 2018..
Individuals aged 30 years or older with no history of dementia who were followed from delivery to December 31, 2021 were identified; The analysis included 1,966,323 people, less than 1 percent of whom developed dementia.
Dementia was defined by the primary hospital admission diagnosis over a mean follow-up period of 9.0 years. The researchers found that, compared with pregnancies without hypertensive disorders, preeclampsia was associated with an increased risk of early-onset dementia (hazard ratio 2.65).
When preeclampsia occurred before 34 weeks' gestation or was superimposed on chronic hypertension, the risk of early-onset dementia was even higher (hazard ratios 4.15 and 4.76, respectively). Severe preeclampsia was not associated with early-onset dementia.
“The results add early-onset preeclampsia to the list of lifetime disease risks or medical consequences of having preeclampsia,” the authors write.