New publications
Protein patterns predict inflammatory bowel disease 16 years before diagnosis
Last reviewed: 03.07.2025
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Scientists from Örebro University (Sweden) have identified specific protein patterns in the blood that can predict inflammatory bowel disease (IBD) 16 years before diagnosis. Early detection of Crohn's disease is particularly accurate.
Key findings of the study:
- An analysis of nearly 800 blood samples showed that a combination of 29 proteins can accurately predict the development of Crohn's disease.
- For ulcerative colitis, a link was also found between changes in protein patterns and future disease progression, but it was less pronounced.
"We have taken an important step towards being able to predict and prevent these diseases at the earliest stages in the future," said Jonas Halfvarsson, professor of gastroenterology and leader of the study.
Detecting markers 16 years before symptoms
- In people who later develop Crohn's disease, changes in protein patterns were visible 16 years before symptoms appeared.
- This discovery may allow for early interventions to improve the quality of life of people at high risk of developing IBD.
"Early detection of these markers provides a chance for timely intervention, which can reduce the risk of complications," Halfvarsson added.
The role of intestinal barrier function and the immune system
- Proteins associated with intestinal barrier function and the immune system play a key role in understanding the mechanisms of Crohn's disease development.
- This will help scientists deepen their understanding of the biological mechanisms of IBD.
The importance of early intervention
One of the main problems with IBD is the silent progression of the disease, in which symptoms appear after damage has occurred in the gastrointestinal tract.
"Despite the significant increase in the number of drugs available, none of them can reverse the damage already done. The earlier we start treatment, the better the prognosis for the patient and the lower the risk of complications," Halfvarsson emphasized.
Conclusion
This study opens new perspectives for the diagnosis and prevention of IBD, focusing on early detection and better understanding of the mechanisms of development of these diseases.
The study was published in the journal Gastroenterology.