A gene responsible for the normal functioning of the immune system was found
Last reviewed: 23.04.2024
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Employees of the Garvan Institute in Sydney (Garvan Institute of Sydney) found the gene STAT3, responsible for the normal operation of immunity.
Australian researchers, thanks to their newest discovery, have identified, due to which it is possible to maintain the correct balance of immunity.
A team led by Cindy Ma and Stuart Tangye found that mutations in the STAT3 gene led to the fact that the body could not produce the main protein of IL-21 immunity (interleukin-21) required for the development of Tfh cells - T-helpers. These cells regulate the reactions of both innate and acquired immunity, and in turn, allow B-lymphocytes (B cells) to produce long-lasting and powerful antibodies that fight infections. So, the lack of antibodies in the human body entails weakened immunity and the occurrence of infection. A surplus can lead to autoimmune diseases, such as lupus, type 1 diabetes and rheumatoid arthritis.
"The STAT3 gene, starting a chain reaction, sends a signal, without which the Tfh cells could not help the B cells," say Sydney scientists.
Developed in the process of disease B cells immunological memory, in the future, enable our body to recognize previously transmitted viruses.
This discovery of Australian scientists gives hope for the cure of immunodeficiency and autoimmune and oncological diseases.
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