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A gene responsible for normal immune function has been discovered
Last reviewed: 01.07.2025
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Researchers at the Garvan Institute of Sydney have discovered the STAT3 gene, which is responsible for normal immune function.
Australian researchers have discovered, thanks to their latest discovery, how the correct immune balance can be maintained.
A team of specialists led by Cindy Ma and Stuart Tangye discovered that mutations in the STAT3 gene prevented the body from producing the main immune protein IL-21 (interleukin-21), which is necessary for the development of Tfh cells – T-helpers. These cells regulate the reactions of both innate and acquired immunity, and in turn, allow B-lymphocytes (B-cells) to produce long-lasting and powerful antibodies that fight infections. Thus, a lack of antibodies in the human body leads to weakened immunity and the occurrence of infection. And an excess can lead to autoimmune diseases such as lupus, type 1 diabetes and rheumatoid arthritis.
"The STAT3 gene, by starting a chain reaction, sends a signal without which the Th cells would not be able to help the B cells," say the Sydney scientists.
The immune memory B cells produced during the disease process enable our body to recognize previously transmitted viruses in the future.
This discovery by Australian scientists gives hope for the cure of immunodeficiency, autoimmune and oncological diseases.
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