The first trimester of pregnancy is the most difficult period of pregnancy and largely determines its course. During this period, the formation of the placenta, embryogenesis and the formation of complex interrelations of the body of the mother and fetus.
Despite the preparation for pregnancy in most women with NLF in previous cycles, pregnancy is problematic. The greatest problems exist in the I trimester in the formation of the placenta, but they often occur in the II and III trimesters due to the formation of primary placental insufficiency, underdevelopment of the myometrium in hypoplasia, infantilism of the uterus.
Treatment is carried out throughout the pregnancy, given the inherent defect of the pathology. If you stop taking dexamethasone, pregnancy can not be interrupted due to the fact that the fetus will take over the supply of glucocorticoids.
At the onset of pregnancy in women with an infectious genesis of miscarriage, control of the activation of bacterial and viral infection is necessary.
In recent years, a transvaginal echographic study has been used to monitor the condition of the cervix. The method of narrowing the cervical canal by creating a muscular duplicate along its lateral walls is the most pathogenetically justified.
In the process of the first trimester, the most important period for autoimmune pathology, we control haemostasis every 2 weeks. From the 2nd day after ovulation in the cycle of conception, the patient receives 1 t (5 mg) of prednisolone or metipreal. Vitamins for pregnant women or metabolic complexes, folic acid and, if necessary, we connect antiplatelet agents and / or anticoagulants.
Glucocorticoid therapy continues with the onset of pregnancy, and the dose is adjusted depending on the specific clinical picture. As a rule, in terms of increasing antibody levels in 20-24, 33-34 weeks of pregnancy, it is advisable to increase the dose of prednisolone by 2.5-5 mg.
The question of the importance of compatibility in the HLA system in the habitual loss of pregnancy is one of the most debated in the literature. In the 80 years there were many publications on this issue.
In the pathogenesis of abortion, the functional state of the central nervous system plays an important role. With adverse effects, it is possible to change activity, both the cerebral cortex and the hypothalamic-pituitary system, which regulates physiological changes in the body to ensure normal development of pregnancy.