The medicine is used in diagnostic procedures, it is only necessary to enter it in / in the method.
It is necessary to follow the generally accepted precautions in the process of performing an MRI: the doctor should first make sure that the patient does not have ferromagnetic implants, a pacemaker, etc.
Dosages in the range 0.14-1.5 T are effective irrespective of the effect of the magnetic field.
The required dosage is given only by injection. Sometimes it is permissible to perform a bolus injection. An MRI scan using contrast enhancement can begin immediately after the medication was administered to the patient.
During the procedure for administering the drug, the patient should, if possible, remain in a supine position. Also, after using the solution, it is necessary to closely monitor the patient's condition, since most adverse reactions occur within a half an hour from the time of administration.
Using a medicine for children (also aged 4 months to 2 years), adolescents, and also adults, the following doses should be used. To increase the contrast and resolve diagnostic issues, it is usually sufficient dosage, which is determined when calculating 0.2 ml / kg.
If after the introduction of such a dosage MRI showed mixed results, but there is a serious suspicion of the presence of pathological entities in the patient, it will be expedient to perform a repeated procedure of drug administration (to clarify the diagnosis). It should be done within half an hour after the 1st procedure, and then perform an MRI. Dosage at the same time remains the same (but for adults, you can calculate the dose of the solution at a parameter of 0.4 ml / kg).
With the exclusion of recurrence of tumor formation or development of metastasis, the increased dosage of drugs used for adults (calculation - 0.6 ml / kg) allows for more accurate diagnosis.
It is allowed to prescribe medication in doses not exceeding 0.4 ml / kg (children over 2 years old) and 0.6 ml / kg (adults).
In the MRI procedure for adults and children (from the age of 4 months), in order to solve the questions raised during the diagnosis, as well as to increase the contrast of the image, a dosage calculated in the 0.2 ml / kg scheme is usually sufficient. But it should be borne in mind that there are only limited information about the experience of conducting MRI procedures of the whole body before the age of 2 years.
In special situations, for example, in the case of tumors that have weak vascularization or a small degree of passage into the extracellular region in order to obtain the required contrast, there may be a need for applying 0.4 ml / kg of the drug. In particular, this applies to low T1-weighted sequences in the scanning procedure.
When visualizing the system of blood vessels (also important here is the area of the body to be examined and the method used to perform it), adults sometimes may need to apply the solution at the maximum dosage.
Children from 1 month to 2 years are allowed to prescribe no more than 0.2 mg / kg of drug solution.
The required amount of solution must be entered manually to prevent the possibility of an unintentional overdose. The procedure using an autoinjector is not performed.
Thus, the following dosages are used for diagnosis:
- the average dose for children (from 1 month to 2 years) and adults for MRI in the whole body area, as well as the brain and spinal cord - 0.2 ml / kg (this is 0.1 mmol / kg);
- the average dose for complex diagnosis (and the maximum allowable in children) is 0.4 ml / kg (which is 0.2 mmol / kg);
- the maximum dosage used to visualize the system of blood vessels is 0.6 ml / kg (which is 0.3 mmol / kg).