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Selegiline
Last reviewed: 10.08.2022
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Release form
Cardboard packaging. Contains three or ten blisters with 10 tablets each.
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Pharmacodynamics
Selegelin is a selective, irreversible MAO inhibitor that destroys dopamine. Acting, he reduces the level of metabolism of dopamine, and thus does not allow him to rise in neurons.
When combined with levodopa, the drug potentiates and prolongs its action, while also reducing side effects. As a result, the dosage of Levodopa can be significantly reduced. But if a person's effectiveness of treatment does not depend on the dosage of Levodopa, he should not prescribe Selegiline.
Pharmacokinetics
For the maximum bioavailability of the active ingredient, the use of food is obligatory. When Selegilin enters the gastrointestinal tract, its rapid absorption takes place. In the blood serum, up to 94% of the substance in the bound form falls. The largest amount of it is formed in an hour or two.
Penetrating the brain and spinal fluid, the drug with derivatives does not accumulate in the tissues, even with prolonged use.
Forming three main derivatives: Selegin - desmethylsegelini, L-amphetamine - L-methamphetamine, the process of metabolism occurs in the liver with a characteristic effect of the first passage.
Isolation of up to 10-85% occurs with the urinary system, the rest is excreted by the intestine.
Dosing and administration
The tablet should be consumed inside immediately after meals in the morning, washed down with a small amount of liquid.
When used in the treatment of only Seleghin or in therapy with decarboxylase and levodopa, the initial dose should be no more than 5-10 mg / day. It is forbidden to take more than 10 mg per day.
After the start of the joint treatment with Levodopa, it is possible to reduce the amount of the second drug to a minimum.
The dose per day can be divided into two doses.
The attending doctor will determine the scheme and duration of treatment, taking into account the effectiveness of the drug.
Contraindications
Seligiline should not be combined with taking Levodopa for patients with thyrotoxicosis, pheochromocytoma, closed-type glaucoma, suffering from high blood pressure and heart palpitations. And also when diagnosing such diseases as benign hyperplasia, angina pectoris and progressive dementia.
Refusal from therapy by Selegilin will be the patient's peptic ulcer, violations of excretory functions of the urinary system and liver.
In addition, the medication is contraindicated in the presence of individual intolerance to any component of the drug.
The drug will not be used in childhood.
Overdose
If the patient complains of dizziness, headache, insomnia, or vice versa, drowsiness, weakness throughout the body, anxiety, chest pain - this may be symptoms of excessive consumption of Selegiline in a dose that exceeds 60 mg / day. Also, the medical worker can note increased or decreased pressure, tachycardia, arrhythmia, confusion, a specific posture with a head tilt and a back arching, a spasm of masticatory muscles.
For treatment, symptomatic therapy is used, since there is no antidote.
Interactions with other drugs
When treating a patient with drugs that serve as serotonin agonists, narcotic analgesics, monoamine oxidase inhibitors, as well as drugs such as Paroxetine, citalopram, sertraline and fluvoxamine, Selegiline is strictly prohibited.
Do not consume alcohol while undergoing treatment with Selegiline. After passing the treatment with this drug, one day after the end of the use of pills, you can begin taking sumatriptan. As for the prima medicaments that block the reuptake of serotonin, we should wait fourteen days.
Seligiline can be prescribed to a patient after the abolition of serotonin reuptake inhibitors no earlier than seven days later, in the case of fluoxetine - this period will increase by five weeks.
It is not necessary to simultaneously carry out treatment with Selegiline drugs related to sympathomimetics.
It should be taken into account that the joint intake of this medication and Levodopa, potentiates and increases the period of action of the latter. And in combination with an anticholinergic group, it is possible to increase the incidence of adverse reactions.
Attention!
To simplify the perception of information, this instruction for use of the drug "Selegiline" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.