Elevit Pronatal

Elevit Pronatal is a mineral multivitamin complex.

Indications of the elevita Pronatal

It is used to prevent the development of mineral-vitamin deficiency (or its correction) at the stage of conception planning, and in addition, already during pregnancy and lactation period.

The drug is applied for a maximum of 1 month before fertilization - to reduce the likelihood of neural tube defects, and in addition to other congenital anomalies in development.

It is also used to prevent the occurrence of anemia, which develops due to a lack of vitamin B9 and iron, and in addition to reducing the incidence of nausea with vomiting in the early stages of pregnancy.

[1], [2]

Release form

Release in tablets, 10 or 20 pieces inside the blister. In a separate package - 3 or 10 blister plates (10 tablets) or 5 blister cells (20 tablets each).

Pharmacodynamics

Elevit Pronatal is a multivitamin-mineral medicine, which contains 12 different vitamins, combined with 3 minerals, and 4 microelements. The drug is designed specifically to provide the pregnant woman and the fetus with optimal micronutrient support.

Vitamins are an essential element in the processes of normal growth and development of both the fetus and the newborn. They help the metabolic processes, as well as the formation of lipids with carbohydrates, proteins with nucleic acids and body energy. In addition, vitamins contribute to the binding of collagen, amino acids and neurotransmitters.

Polyvitamin-polymineral medicines are used to prevent or correct a food insufficiency of the organism in micronutrients. During pregnancy, as well as lactation in the body, there is an increased need for micronutrients, which increases the likelihood of the deficiency of this component in both the woman and the fetus / child.

During the evaluation of the safety and efficacy of the drug at the conception planning stage (1 month before conception, and up to the 3rd month of the gestation period), it was not possible to detect defects in the neural tube (compared with 6 cases in the placebo group) . The difference was statistically significant and was confirmed during the following pharmacoepidemiological two-spot testing: in the group that took the medicine, only one case was noted with the development of a defect in the region of the neural tube; In a group that did not take vitamins, 9 such cases were noted. In addition, both tests showed that the overall index of the coarse anomaly in development (for example, defects in the CCC and urinary system, as well as limbs and obstruction of the pylorus) is lower in the group who took Elevit Pronatal (a comparison with the placebo group or a control group that did not take vitamins). Together with this, it was found that within the group using drugs, cases of vomiting with nausea as well as dizziness (comparison with the placebo category) were half as rare.

Indices of folate inside the erythrocytes of a pregnant woman is a reflection of the degree of probability of a defect in the area of the neural tube in the developing fetus. The folate thresholds, which are associated with a low probability of occurrence of these defects, are 906 nmol / L.

It is recommended to take the drug at the planning stage of conception, because anomalies in the development of the fetal neural tube occur already in the first weeks, even before the presence of pregnancy can be established.

[3]

Dosing and administration

The medicine should be taken on the first pill per day (in the morning, along with the food), washing it with water. You can not chew the pill. If nausea is observed, it is recommended to take the medicine in the afternoon or evening.

Take the drug is recommended in the period of 1 month before the planned conception, and then during pregnancy and lactation. Elevit Pronatal is intended for use by women who are in reproductive age.

[10], [11], [12]

Use of the elevita Pronatal during pregnancy

Elevit Pronatal is designed specifically for lactation / pregnancy, but the size of daily doses should be controlled, avoiding exceeding them. Before taking a consultation with the doctor.

Retinol in daytime dosages of more than 10 thousand IU, administered at the 1 st trimester, had a teratogenic effect. Because of this, it is required to carefully take the medicine in combination with other drugs, which contain retinol. In addition, it should not be combined with artificial isomers (isotretinoin, as well as etretinate) or β-carotene, because the elements indicated above are harmful to the fetus.

Chronic poisoning with calciferol can adversely affect the fetus. It is required to prevent overdoses by this element, because chronic hypercalcemia can cause a delay in development (mental and physical), and in addition the development of aortic or supra-valence stenosis and retinopathy.

It was found that intoxication with calciferol in pregnant animals led to the development of teratogenic effects. But there is no evidence that the therapeutic dosages of calciferol are capable of having a teratogenic effect on humans.

Contraindications

The main contraindications:

• the presence of hypersensitivity to the constituent components of the drug;
• hypervitaminosis of type A or D;
• combined reception with retinoids;
• functional renal impairment in severe form;
• Disorders of the processes of copper or iron exchange;
• hypercalcemia or hypercalciuria (in severe form);
• a history of sarcoidosis;
• pulmonary tuberculosis in active form;
• exacerbated ulcer in the area of the 12-intestine or stomach;
• hypervitaminosis of type E.

[4], [5], [6]

Side effects of the elevita Pronatal

Use of the medicine can lead to the appearance of such side effects:

• disorders of the gastrointestinal tract: dyspeptic manifestations (this includes abdominal pain and discomfort, as well as pain in the digestive tract), constipation, nausea, flatulence, diarrhea and vomiting;
• immune disorders: manifestations of allergy (this includes the reactions of anaphylaxis), as well as facial swelling, hives, skin redness and dyspnea. In addition, there is an asthmatic syndrome, blisters, as well as a shock, itching and rashes. When allergic symptoms appear, it is necessary to cancel the medicine and consult the doctor;
• metabolic disorders: the development of hypercalcemia or hypercalciuria;
• manifestations from the NA: there may be dizziness, hyperthermia, headaches, and besides sensation of drowsiness or increased excitability, as well as insomnia.

Because of the riboflavin contained in the drug, a weak coloration of the urine can be observed in yellow, while another component component of the drug, iron, is capable of staining black faeces. These effects are completely safe for health.

During the placebo-controlled test, pregnant women received daily 1 tablet of drugs in the period of 6 months. At the same time, side effects such as skin rashes, diarrhea and diarrhea were noted.

[7], [8], [9]

Overdose

Cases of intoxication were often associated with simultaneous administration of monopreparations or multivitamins in large doses. With prolonged or acute overdose, it is possible to develop hypervitaminosis of type A or D, and hypercalcemia in addition. Copper with iron poisoning can have a toxic effect.

Among the symptoms of acute intoxication - nonspecific signs in the form of a sudden headache, and in addition suppression of consciousness and abnormal function of the digestive tract (nausea, diarrhea, constipation and vomiting). If these symptoms appear, you should cancel the drug and consult a doctor.

Poisoning with ascorbic acid (intake in a dosage that exceeds 15 g) can cause hemolytic-type anemia in some people (deficient in G6PD).

In the case of long-term use of large doses of drugs, arrhythmia, irritation of the mucous membranes, hyperuricemia and paresthesia may occur, and hyperglycemia, a decrease in glucose tolerance, and a disorder of renal function. There may also be a transient increase in LDH, ACP, and AST activity, cracks and dryness in the area of the feet with palms, seborrheic type and alopecia.

[13], [14]

Interactions with other drugs

Eleate Pronatal elements can interact with such medications:

• it is possible to suppress iron absorption in the case of a combination with antacids, drugs that lower the pH level in the stomach, bisphosphonates, penicillamine, and also levodopa, fluoroquinolones, levothyroxine and tetracyclines. If this combination is necessary, it is necessary to take medication with an interval of 2-3 hours;
• Magnesium or calcium-containing drugs, as well as drugs containing zinc or copper, are able to interact with antibiotics (such as fluoroquinolones and tetracyclines), as well as with antacids, penicillamine, levodopa, thyroxine, and in addition to bisphosphonates, triene , antiviral drugs, digitalis and oral diuretics of the thiazide type. Because of this, people who use such drugs in combination need to observe the interval between receptions at 2 hours;
• Diuretics of the thiazide type can inhibit calcium in the body - this increases the likelihood of hypercalcemia;
• vitamin B9 potentiates the metabolism of phenytoin;
• ascorbic acid increases the effectiveness of the action, as well as adverse reactions of antimicrobial drugs from the category of sulfonamides;
• the absorption of tocopherol can disrupt the action of drugs of silver or iron.

Because oxalic (found in rhubarb and spinach) and myo-inositol-hexaphosphoric (found inside whole grains), acids can inhibit the absorption of calcium, it is forbidden to take the medicine within 2 hours after eating a meal that contains a high index of these acids.

[15], [16], [17], [18]

Storage conditions

Keep the tablets in a place inaccessible to children. Temperature values are a maximum of 25 ° C.

[19], [20], [21]

Special instructions

Reviews

According to reviews, the use of the drug during conception planning has a positive effect on the course of pregnancy. In addition, doctors note that the probability of conception in this case is significantly increased, because the body has the required amount of all necessary fractions of nutrient components. In this case, the fetus develops without being exposed to the risk of various diseases that are possible in the case of a lack of vitamins. And microelements stimulate the optimal laying of organs important for life with tissues.

Shelf life

Elevit Pronatal is allowed to be used in the period of 2 years from the date of release of the medicine.